Diazoxide drug interactions: Difference between revisions

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==Drug Interactions==
==Drug Interactions==


===Effects of other drugs===
Since diazoxide is highly bound to serum proteins, it may displace other substances which are also bound to protein, such as [[bilirubin]] or [[coumarin]]and its derivatives, resulting in higher blood levels of these substances. Concomitant administration of oral diazoxide and [[diphenylhydantoin]] may result in a loss of [[seizure]] control. These potential interactions must be considered when administering PROGLYCEM® Capsules or Suspension.
 
Ticagrelor is predominantly metabolized by CYP3A4 and to a lesser extent by CYP3A5. Ticagrelor is also a p-glycoprotein (P-gp) substrate.
 
===7.1 CYP3A inhibitors===
 
Avoid use of strong inhibitors of CYP3A (e.g., [[ketoconazole]], [[itraconazole]], [[voriconazole]], [[clarithromycin]], [[nefazodone]], [[ritonavir]], [[saquinavir]], [[nelfinavir]], [[indinavir]], [[atazanavir]] and [[telithromycin]]) [see Warnings and Precautions (5.6) and Clinical Pharmacology (12.3)].
 
===7.2 CYP3A inducers===
 
Avoid use with potent inducers of CYP3A (e.g., [[rifampin]], [[dexamethasone]], [[phenytoin]], [[carbamazepine]] and [[phenobarbital]]) [see Warnings and Precautions (5.7) and Clinical Pharmacology (12.3)].
 
===7.3 Aspirin===
 
Use of BRILINTA with [[aspirin]] maintenance doses above 100 mg reduced the effectiveness of BRILINTA [see Warnings and Precautions (5.2) and Clinical Studies(14)].
 
Effect of BRILINTA on other drugs
 
Ticagrelor is an inhibitor of CYP3A4/5 and the P-glycoprotein transporter.
 
===7.4 Simvastatin, lovastatin===
 
BRILINTA will result in higher serum concentrations of [[simvastatin]] and [[lovastatin]] because these drugs are metabolized by CYP3A4. Avoid simvastatin and [[lovastatin]] doses greater than 40 mg [see Clinical Pharmacology (12.3)].
 
===7.5 Digoxin===
 
[[Digoxin]]: Because of inhibition of the P-glycoprotein transporter, monitor digoxin levels with initiation of or any change in BRILINTA therapy [see Clinical Pharmacology(12.3)].
 
===7.6 Other Concomitant Therapy===
 
BRILINTA can be administered with unfractionated or low-molecular-weight heparin, GPIIb/IIIa inhibitors, proton pump inhibitors, [[beta-blockers]], [[angiotensin converting enzyme inhibitors]], and [[angiotensin receptor blockers]].<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = PROGLYCEM (DIAZOXIDE) SUSPENSION [TEVA GLOBAL RESPIRATORY RESEARCH LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b16c7832-2fd9-49af-b923-1dc0d91fd6e2 | publisher =  | date =  | accessdate = 26 February 2014 }}</ref>


The concomitant administration of [[thiazides]] or other commonly used [[diuretics]] may potentiate the hyperglycemic and hyperuricemic effects of diazoxide.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = PROGLYCEM (DIAZOXIDE) SUSPENSION [TEVA GLOBAL RESPIRATORY RESEARCH LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b16c7832-2fd9-49af-b923-1dc0d91fd6e2 | publisher =  | date =  | accessdate = 26 February 2014 }}</ref>
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 18:50, 26 February 2014

Diazoxide
PROGLYCEM® FDA Package Insert
Indications and Usage
Dosage and Administration
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
How Supplied/Storage and Handling
Labels and Packages
Clinical Trials on Diazoxide
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]

Drug Interactions

Since diazoxide is highly bound to serum proteins, it may displace other substances which are also bound to protein, such as bilirubin or coumarinand its derivatives, resulting in higher blood levels of these substances. Concomitant administration of oral diazoxide and diphenylhydantoin may result in a loss of seizure control. These potential interactions must be considered when administering PROGLYCEM® Capsules or Suspension.

The concomitant administration of thiazides or other commonly used diuretics may potentiate the hyperglycemic and hyperuricemic effects of diazoxide.[1]

References

  1. ↑ "PROGLYCEM (DIAZOXIDE) SUSPENSION [TEVA GLOBAL RESPIRATORY RESEARCH LLC]". Retrieved 26 February 2014.

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