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<small>'''''Synonyms / Brand Names:''''' Adalat, Adalat 10, Adalat 20, Adalat 5, Adalat CC, Adalat CR, Adalat Crono, Adalat Ft, Adalat Gits, Adalat Gits 30, Adalat LA, Adalat LP, Adalat Oros,Adalat PA, Adalat Retard, Adalate, Adapine, Adapress, Alat, Aldipin, Alfadal, Alonix, Alonix S, Alpha-Nifedipine Retard, Angipec, Anifed, Anpine, Apo-Nifed, Aprical, Bonacid, Calcibloc, Calcigard, Calcilat, Camont, Cardifen, Cardilat, Cardionorm, Chronadalate, Chronadalate Lp, Citilat, Coracten, Coral, Cordafen, Cordaflex, Cordalat, Cordicant, Cordilan, Cordipin, Corinfar, Corotrend, Corynphar, Depin, Dignokonstant, Dilafed, Dilcor, Dipinkor, Duranifin, Ecodipi, Ecodipin, Ecodipin E, Fedcor, Fedcor Retard, Fenamon, Fenamon Sr, Fenihidin, Fenihidine, Glopir, Hadipin, Hexadilat, Introcar, Kordafen, Macorel, Megalat, Myogard, N1fedilat, Nedipin, Nicardia, Nifangin, Nifar, Nifdemin, Nifebene, Nifecard, Nifecor, Nifedepat, Nifedicor, Nifedin, Nifedine, Nifedipine Retard, Nifedipres, Nifedirex LP, Nifelan, Nifelat, Nifelat Q, Nifelate, Nifensar XL, Nificard, Nifidine, Nifipen, Niphedipine, Orix, Oxcord, Pidilat, Procardia, Procardia XL, Sepamit, Tibricol, Zenusin </small>
__NOTOC__
{{Nifedipine}}
{{CMG}}; {{AE}}: {{AK}}


{{CMG}}
'''''For patient information about Nifedipine, click [[Nifedipine (patient information)|here]].'''''


==Dosing and Administration==
{{SB}}Adalat<sup>®</sup>, Adalat 10<sup>®</sup>, Adalat 20<sup>®</sup>, Adalat 5<sup>®</sup>, Adalat CC<sup>®</sup>, Adalat CR<sup>®</sup>, Adalat Crono<sup>®</sup>, Adalat Ft<sup>®</sup>, Adalat Gits<sup>®</sup>, Adalat Gits 30<sup>®</sup>, Adalat LA<sup>®</sup>, Adalat LP<sup>®</sup>, Adalat Oros<sup>®</sup>,Adalat PA<sup>®</sup>, Adalat Retard<sup>®</sup>, Adalate<sup>®</sup>, Adapine<sup>®</sup>, Adapress<sup>®</sup>, Alat<sup>®</sup>, Aldipin<sup>®</sup>, Alfadal<sup>®</sup>, Alonix<sup>®</sup>, Alonix S<sup>®</sup>, Alpha-Nifedipine Retard<sup>®</sup>, Angipec<sup>®</sup>, Anifed<sup>®</sup>, Anpine<sup>®</sup>, Apo-Nifed<sup>®</sup>, Aprical<sup>®</sup>, Bonacid<sup>®</sup>, Calcibloc<sup>®</sup>, Calcigard<sup>®</sup>, Calcilat<sup>®</sup>, Camont<sup>®</sup>, Cardifen<sup>®</sup>, Cardilat<sup>®</sup>, Cardionorm<sup>®</sup>, Chronadalate<sup>®</sup>, Chronadalate Lp<sup>®</sup>, Citilat<sup>®</sup>, Coracten<sup>®</sup>, Coral<sup>®</sup>, Cordafen<sup>®</sup>, Cordaflex<sup>®</sup>, Cordalat<sup>®</sup>, Cordicant<sup>®</sup>, Cordilan<sup>®</sup>, Cordipin<sup>®</sup>, Corinfar<sup>®</sup>, Corotrend<sup>®</sup>, Corynphar<sup>®</sup>, Depin<sup>®</sup>, Dignokonstant<sup>®</sup>, Dilafed<sup>®</sup>, Dilcor<sup>®</sup>, Dipinkor<sup>®</sup>, Duranifin<sup>®</sup>, Ecodipi<sup>®</sup>, Ecodipin<sup>®</sup>, Ecodipin E<sup>®</sup>, Fedcor<sup>®</sup>, Fedcor Retard<sup>®</sup>, Fenamon<sup>®</sup>, Fenamon Sr<sup>®</sup>, Fenihidin<sup>®</sup>, Fenihidine<sup>®</sup>, Glopir<sup>®</sup>, Hadipin<sup>®</sup>, Hexadilat<sup>®</sup>, Introcar<sup>®</sup>, Kordafen<sup>®</sup>, Macorel, Megalat<sup>®</sup>, Myogard<sup>®</sup>, N1fedilat<sup>®</sup>, Nedipin<sup>®</sup>, Nicardia<sup>®</sup>, Nifangin<sup>®</sup>, Nifar<sup>®</sup>, Nifdemin<sup>®</sup>, Nifebene<sup>®</sup>, Nifecard<sup>®</sup>, Nifecor<sup>®</sup>, Nifedepat<sup>®</sup>, Nifedicor<sup>®</sup>, Nifedin<sup>®</sup>, Nifedine<sup>®</sup>, Nifedipine Retard<sup>®</sup>, Nifedipres<sup>®</sup>, Nifedirex LP<sup>®</sup>, Nifelan<sup>®</sup>, Nifelat<sup>®</sup>, Nifelat Q<sup>®</sup>, Nifelate<sup>®</sup>, Nifensar XL<sup>®</sup>, Nificard<sup>®</sup>, Nifidine<sup>®</sup>, Nifipen<sup>®</sup>, Niphedipine<sup>®</sup>, Orix<sup>®</sup>, Oxcord<sup>®</sup>, Pidilat<sup>®</sup>, Procardia<sup>®</sup>, Procardia XL<sup>®</sup>, Sepamit<sup>®</sup>, Tibricol<sup>®</sup>, Zenusin<sup>®</sup>
Dosage must be adjusted according to each patient's needs. Therapy for either hypertension or angina should be initiated with 30 or 60 mg once daily. Nifedipine extended-release tablets should be swallowed whole and should not be bitten or divided. In general, titration should proceed over a 7–14 day period so that the physician can fully assess the response to each dose level and monitor blood pressure before proceeding to higher doses. Since steady-state plasma levels are achieved on the second day of dosing, if symptoms so warrant, titration may proceed more rapidly provided the patient is assessed frequently. Titration to doses above 120 mg are not recommended
==Overview==
<br>
'''Nifedipine''' is a [[dihydropyridine]] [[calcium channel blocker]] that primarily blocks [[L-type calcium channels]].<ref>{{cite journal |author=Hayashi K, Homma K, Wakino S, Tokuyama H, Sugano N, Saruta T, Itoh H |title=T-type Ca channel blockade as a determinant of kidney protection |journal=Keio J Med |volume=59 |issue=3 |pages=84–95 |year=2010 |pmid=20881449 |doi=10.2302/kjm.59.84}}</ref> Its main uses are as an [[antianginal]] (especially in [[Prinzmetal's angina]]) and [[antihypertensive]], although a large number of other indications have recently been found for this agent, such as [[Raynaud's phenomenon]], [[Premature birth|premature labor]], and painful spasms of the [[esophagus]] such as in [[cancer]] and [[tetanus]] patients. It is also commonly used for the small subset of [[pulmonary hypertension]] patients whose symptoms respond to [[calcium channel blockers]].
----
==Category==
<br>
[[Calcium channel blockers]].
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==FDA Package Insert==
[[{{PAGENAME}}#FDA Package Insert Resources|FDA Package Insert Resources]]
<br></font size><small>Indications, Contraindications, Side Effects, Drug Interactions, etc.</small><font size="4"><br>
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[http://www.pace-med-apps.com/gfrcalc.htm Calculate Creatine Clearance]
<br></font size><small>On line calculator of your patients Cr Cl by a variety of formulas.</small><font size="4"><br>
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[http://home.earthlink.net/~sensei11/convert.htm Convert pounds to Kilograms]
<br></font size><small>On line calculator of your patients weight in pounds to Kg for dosing estimates.</small><font size="4"><br>
<br> [[{{PAGENAME}}#Publication Resources|Publication Resources]]
<br></font size><small>Recent articles, WikiDoc State of the Art Review, Textbook Information</small><font size="4"><br>
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[[{{PAGENAME}}#Trial Resources|Trial Resources]]
<br></font size><small>Ongoing Trials, Trial Results</small><font size="4"><br>
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[[{{PAGENAME}}#Guidelines & Evidence Based Medicine Resources|Guidelines & Evidence Based Medicine Resources]]
<br></font size><small>US National Guidelines, Cochrane Collaboration, etc.</small><font size="4"><br>
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[[{{PAGENAME}}#Media Resources|Media Resources]]
<br></font size><small>Slides, Video, Images, MP3, Podcasts, etc.</small><font size="4"><br><br>
[[{{PAGENAME}}#Patient Resources|Patient Resources]]
<br></font size><small>Discussion Groups, Handouts, Blogs, News, etc.</small><font size="4"><br>
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[[{{PAGENAME}}#International Resources|International Resources]]
<br></font size><small>en Español</small><font size="4"><br>
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==FDA Package Insert Resources==
====NIFEDIPINE<sup>®</sup>====
[[{{PAGENAME}} indications|Indications]]
'''  [[Nifedipine indications and usage|Indications and Usage]]'''
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'''| [[Nifedipine dosage and administration|Dosage and Administration]]'''
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'''| [[Nifedipine dosage forms and strengths|Dosage Forms and Strengths]]'''
[[{{PAGENAME}} contraindications|Contraindications]]
'''| [[Nifedipine contraindications|Contraindications]]'''
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'''| [[Nifedipine warnings and precautions|Warnings and Precautions]]'''
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'''| [[Nifedipine adverse reactions|Adverse Reactions]]'''
[[{{PAGENAME}} side effects|Side Effects]]
'''| [[Nifedipine drug interactions|Drug Interactions]]'''
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'''| [[Nifedipine use in specific populations|Use in Specific Populations]]'''
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'''| [[Nifedipine overdosage|Overdosage]]'''
[[{{PAGENAME}} drug interactions|Drug Interactions]]
'''| [[Nifedipine description|Description]]'''
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'''| [[Nifedipine clinical pharmacology|Clinical Pharmacology]]'''
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'''| [[Nifedipine nonclinical toxicology|Nonclinical Toxicology]]'''
[[{{PAGENAME}} precautions|Precautions]]
'''| [[Nifedipine clinical studies|Clinical Studies]]'''
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'''| [[Nifedipine how supplied storage and handling|How Supplied/Storage and Handling]]'''
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'''| [[Nifedipine patient counseling information|Patient Counseling Information]]'''
[[{{PAGENAME}} overdose|Overdose]]
'''| [[Nifedipine labels and packages|Labels and Packages]]'''
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[[{{PAGENAME}} instructions for administration|Instructions for Administration]]
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[[{{PAGENAME}} how supplied|How Supplied]]
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[[{{PAGENAME}} pharmacokinetics and molecular data|Pharmacokinetics and Molecular Data]]
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[http://www.fda.gov/cder/foi/nda/99/75108_Nifedipine_prntlbl.pdf FDA label]
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[http://google2.fda.gov/search?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&x=0&y=0&client=FDA&site=FDA&lr=&proxystylesheet=FDA&output=xml_no_dtd&getfields=* FDA on {{PAGENAME}}]
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</font size><small>[[{{PAGENAME}}#Dosing and Administration|Return to top]]</small><font size="4">
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==Publication Resources==
==Mechanism of Action==
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Most Recent Articles on {{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}]
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[http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}%20AND%20systematic%5Bsb%5D  Review Articles on {{PAGENAME}}]
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+AND+%28%28N+Engl+J+Med%5Bta%5D%29+OR+%28Lancet%5Bta%5D%29+OR+%28BMJ%5Bta%5D%29%29 Articles on {{PAGENAME}} in N Eng J Med, Lancet, BMJ]
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[[Nifedipine detailed information|WikiDoc State of the Art Review]]
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[http://books.google.com/books?ie=UTF-8&oe=utf-8&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&qt_s=Search&sa=N&tab=gp Textbook Information on {{PAGENAME}}]
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==Trial Resources==
==References==
[http://clinicaltrials.gov/search/open/condition={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Ongoing Trials with {{PAGENAME}} at Clinical Trials.gov]
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+AND+%28randomized+controlled+trial%5BPublication+Type%5D+OR+%28randomized%5BTitle%2FAbstract%5D+AND+controlled%5BTitle%2FAbstract%5D+AND+trial%5BTitle%2FAbstract%5D%29%29 Trial Results with {{PAGENAME}}]
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</font size><small>[[{{PAGENAME}}#Dosing and Administration|Return to top]]</small><font size="4">
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==Guidelines & Evidence Based Medicine Resources==
[http://www.guideline.gov/search/searchresults.aspx?Type=3&txtSearch={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&num=20 US National Guidelines Clearinghouse on {{PAGENAME}}]
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:({{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}) AND (Cochrane Database Syst Rev[ta])}} Cochrane Collaboration on {{PAGENAME}}]
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:({{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}) AND (Cost effectiveness)}} Cost Effectiveness of {{PAGENAME}}]
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</font size><small>[[{{PAGENAME}}#Dosing and Administration|Return to top]]</small><font size="4">
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==Media Resources==
[http://www.google.com/search?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+ppt&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a Powerpoint Slides on {{PAGENAME}}]
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[http://images.google.com/images?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&ie=UTF-8&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&sa=N&tab=wi Images of {{PAGENAME}}]
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[http://www.google.com/search?hl=en&client=firefox-a&rls=org.mozilla%3Aen-US%3Aofficial&hs=hPo&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+podcasts+OR+MP3&btnG=Search Podcasts & MP3s on {{PAGENAME}}]
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[http://video.google.com/videosearch?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&ie=UTF-8&oe=utf-8&rls=org.mozilla:en-US:official&um=1&sa=N&tab=fv# Videos on {{PAGENAME}}]
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</font size><small>[[{{PAGENAME}}#Dosing and Administration|Return to top]]</small><font size="4">
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==Patient Resources==
[[{{PAGENAME}} (patient information)|Patient Information from National Library of Medicine]]
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[http://www.google.com/search?hl=en&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+more:for_patients&cx=disease_for_patients&sa=N&oi=cooptsr&resnum=0&ct=col3&cd=1  Patient Resources on {{PAGENAME}}]
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[http://groups.google.com/groups/search?ie=UTF-8&oe=utf-8&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&qt_s=Search Discussion Groups on {{PAGENAME}}]
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[http://www.google.com/search?hl=en&client=firefox-a&rls=org.mozilla:en-US:official&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+more:patient_handouts&cx=disease_for_health_professionals&sa=N&oi=coopctx&resnum=0&ct=col1&cd=3 Patient Handouts on {{PAGENAME}}]
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[http://blogsearch.google.com/blogsearch?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&ie=UTF-8&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&sa=N&tab=wb Blogs on {{PAGENAME}}]
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[http://news.google.com/news?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&ie=UTF-8&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&sa=N&tab=wn {{PAGENAME}} in the News]
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[http://finance.google.com/finance?ie=UTF-8&oe=utf-8&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&qt_s=Search&sa=N&tab=te {{PAGENAME}} in the Marketplace]
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</font size><small>[[{{PAGENAME}}#Dosing and Administration|Return to top]]</small><font size="4">
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==International Resources==
[http://www.google.com/search?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+en+espanol&ie=utf-8&oe=utf-8&aq=t&rls=org.mozilla:en-US:official&client=firefox-a {{PAGENAME}} en Español]
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{{FDA}}


{{Reflist|2}}
http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=03be089c-07e5-4f94-bfcc-c6101b311785
[[Category:Cardiovascular Drugs]]
[[Category:Drugs]]
[[Category:Drugs]]

Revision as of 20:21, 26 February 2014

Nifedipine
NIFEDIPINE® FDA Package Insert
Indications and Usage
Dosage and Administration
Dosage Forms and Strengths
Contraindications
Warnings
Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
Clinical Trials on Nifedipine
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: : Abdurahman Khalil, M.D. [2]

For patient information about Nifedipine, click here.

Synonyms / Brand Names:Adalat®, Adalat 10®, Adalat 20®, Adalat 5®, Adalat CC®, Adalat CR®, Adalat Crono®, Adalat Ft®, Adalat Gits®, Adalat Gits 30®, Adalat LA®, Adalat LP®, Adalat Oros®,Adalat PA®, Adalat Retard®, Adalate®, Adapine®, Adapress®, Alat®, Aldipin®, Alfadal®, Alonix®, Alonix S®, Alpha-Nifedipine Retard®, Angipec®, Anifed®, Anpine®, Apo-Nifed®, Aprical®, Bonacid®, Calcibloc®, Calcigard®, Calcilat®, Camont®, Cardifen®, Cardilat®, Cardionorm®, Chronadalate®, Chronadalate Lp®, Citilat®, Coracten®, Coral®, Cordafen®, Cordaflex®, Cordalat®, Cordicant®, Cordilan®, Cordipin®, Corinfar®, Corotrend®, Corynphar®, Depin®, Dignokonstant®, Dilafed®, Dilcor®, Dipinkor®, Duranifin®, Ecodipi®, Ecodipin®, Ecodipin E®, Fedcor®, Fedcor Retard®, Fenamon®, Fenamon Sr®, Fenihidin®, Fenihidine®, Glopir®, Hadipin®, Hexadilat®, Introcar®, Kordafen®, Macorel, Megalat®, Myogard®, N1fedilat®, Nedipin®, Nicardia®, Nifangin®, Nifar®, Nifdemin®, Nifebene®, Nifecard®, Nifecor®, Nifedepat®, Nifedicor®, Nifedin®, Nifedine®, Nifedipine Retard®, Nifedipres®, Nifedirex LP®, Nifelan®, Nifelat®, Nifelat Q®, Nifelate®, Nifensar XL®, Nificard®, Nifidine®, Nifipen®, Niphedipine®, Orix®, Oxcord®, Pidilat®, Procardia®, Procardia XL®, Sepamit®, Tibricol®, Zenusin®

Overview

Nifedipine is a dihydropyridine calcium channel blocker that primarily blocks L-type calcium channels.[1] Its main uses are as an antianginal (especially in Prinzmetal's angina) and antihypertensive, although a large number of other indications have recently been found for this agent, such as Raynaud's phenomenon, premature labor, and painful spasms of the esophagus such as in cancer and tetanus patients. It is also commonly used for the small subset of pulmonary hypertension patients whose symptoms respond to calcium channel blockers.

Category

Calcium channel blockers.

FDA Package Insert

NIFEDIPINE®

Indications and Usage | Dosage and Administration | Dosage Forms and Strengths | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Use in Specific Populations | Overdosage | Description | Clinical Pharmacology | Nonclinical Toxicology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages

Mechanism of Action

References

  1. ↑ Hayashi K, Homma K, Wakino S, Tokuyama H, Sugano N, Saruta T, Itoh H (2010). "T-type Ca channel blockade as a determinant of kidney protection". Keio J Med. 59 (3): 84–95. doi:10.2302/kjm.59.84. PMID 20881449.

http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=03be089c-07e5-4f94-bfcc-c6101b311785

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