Thymoma historical perspective: Difference between revisions
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{{CMG}}; {{AE}} {{AM}} | {{CMG}}; {{AE}} {{AM}} | ||
==Overview== | |||
Thymomas are developed from the thymic epithelium which has been considered to have a dual origin. However, a growing body of evidence supports that the diverse thymic microenvironment originates from endodermal progenitor cells. | |||
==Historical Perspective== | ==Historical Perspective== | ||
Recent evidence | |||
It has been believed that thymic epithelium is derived from both [[ectoderm]]al and [[endoderm]]al stem cells. Recent evidence indicates that epithelial populations originate from a common progenitor of endodermal origin. This concept does not exclude the occurrence of more differentiated “committed stem cells” with medullary, cortical or other phenotypes.<ref name="Blackburn-2002">{{Cite journal | last1 = Blackburn | first1 = CC. | last2 = Manley | first2 = NR. | last3 = Palmer | first3 = DB. | last4 = Boyd | first4 = RL. | last5 = Anderson | first5 = G. | last6 = Ritter | first6 = MA. | title = One for all and all for one: thymic epithelial stem cells and regeneration. | journal = Trends Immunol | volume = 23 | issue = 8 | pages = 391-5 | month = Aug | year = 2002 | doi = | PMID = 12133801 }}</ref><ref name="Gill-2002">{{Cite journal | last1 = Gill | first1 = J. | last2 = Malin | first2 = M. | last3 = Holländer | first3 = GA. | last4 = Boyd | first4 = R. | title = Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells. | journal = Nat Immunol | volume = 3 | issue = 7 | pages = 635-42 | month = Jul | year = 2002 | doi = 10.1038/ni812 | PMID = 12068292 }}</ref> | |||
==References== | ==References== | ||
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[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
Revision as of 19:25, 28 February 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amr Marawan, M.D. [2]
Overview
Thymomas are developed from the thymic epithelium which has been considered to have a dual origin. However, a growing body of evidence supports that the diverse thymic microenvironment originates from endodermal progenitor cells.
Historical Perspective
It has been believed that thymic epithelium is derived from both ectodermal and endodermal stem cells. Recent evidence indicates that epithelial populations originate from a common progenitor of endodermal origin. This concept does not exclude the occurrence of more differentiated “committed stem cells” with medullary, cortical or other phenotypes.[1][2]
References
- ↑ Blackburn, CC.; Manley, NR.; Palmer, DB.; Boyd, RL.; Anderson, G.; Ritter, MA. (2002). "One for all and all for one: thymic epithelial stem cells and regeneration". Trends Immunol. 23 (8): 391–5. PMID 12133801. Unknown parameter
|month=ignored (help) - ↑ Gill, J.; Malin, M.; Holländer, GA.; Boyd, R. (2002). "Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells". Nat Immunol. 3 (7): 635–42. doi:10.1038/ni812. PMID 12068292. Unknown parameter
|month=ignored (help)