Verapamil hydrochloride injection adverse reactions: Difference between revisions
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==ADVERSE REACTIONS== | |||
The following reactions were reported with verapamil hydrochloride injection used in controlled U.S. clinical trials involving 324 patients: | |||
'''Cardiovascular:''' Symptomatic [[hypotension ]](1.5%); [[bradycardia ]](1.2%); severe [[tachycardia ]](1.0%). The worldwide experience in open clinical trials in more than 7,900 patients was similar. | |||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = VERAPAMIL HYDROCHLORIDE INJECTION, SOLUTION [CARDINAL HEALTH] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0c27c868-7eae-4b3e-babf-e89404ea27b7#nlm34090-1 | publisher = | date = | accessdate = }}</ref> | '''Central Nervous System Effects:''' [[Dizziness ]](1.2%); [[headache ]](1.2%). Occasional cases of seizures during verapamil injection have been reported. | ||
'''Gastrointestinal:''' [[Nausea ]](0.9%); abdominal discomfort (0.6%). | |||
In rare cases of hypersensitive patients, broncho/laryngeal spasm accompanied by itch and urticaria has been reported. | |||
The following reactions have been reported at low frequency: emotional depression, rotary [[nystagmus]], [[sleepiness]], [[vertigo]], muscle [[fatigue]], [[diaphoresis]], and[[ respiratory failure]]. | |||
[[image:verainj2.png]] | |||
*Actual treatment and dosage should depend on the severity of the clinical situation and the judgment and experience of the treating physician.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = VERAPAMIL HYDROCHLORIDE INJECTION, SOLUTION [CARDINAL HEALTH] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0c27c868-7eae-4b3e-babf-e89404ea27b7#nlm34090-1 | publisher = | date = | accessdate = }}</ref> | |||
Revision as of 23:17, 4 March 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdurahman Khalil, M.D. [2]
ADVERSE REACTIONS
The following reactions were reported with verapamil hydrochloride injection used in controlled U.S. clinical trials involving 324 patients:
Cardiovascular: Symptomatic hypotension (1.5%); bradycardia (1.2%); severe tachycardia (1.0%). The worldwide experience in open clinical trials in more than 7,900 patients was similar.
Central Nervous System Effects: Dizziness (1.2%); headache (1.2%). Occasional cases of seizures during verapamil injection have been reported.
Gastrointestinal: Nausea (0.9%); abdominal discomfort (0.6%).
In rare cases of hypersensitive patients, broncho/laryngeal spasm accompanied by itch and urticaria has been reported.
The following reactions have been reported at low frequency: emotional depression, rotary nystagmus, sleepiness, vertigo, muscle fatigue, diaphoresis, andrespiratory failure.
- Actual treatment and dosage should depend on the severity of the clinical situation and the judgment and experience of the treating physician.[1]