Verapamil hydrochloride injection overdosage: Difference between revisions
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Treatment of overdosage should be supportive and individualized. Beta-adrenergic stimulation and/or parenteral administration of calcium injections may increase calcium ion flux across the slow channel, and have been effectively used in treatment of deliberate overdosage with oral verapamil hydrochloride. Verapamil cannot be removed by hemodialysis. | Treatment of overdosage should be supportive and individualized. Beta-adrenergic stimulation and/or parenteral administration of calcium injections may increase calcium ion flux across the slow channel, and have been effectively used in treatment of deliberate overdosage with oral verapamil hydrochloride. Verapamil cannot be removed by hemodialysis. | ||
Clinically significant [[hypotensive ]]reactions or high-degree [[AV block]] should be treated with vasopressor agents or cardiac pacing, respectively. [[Asystole ]]should be handled by the usual measures including [[isoproterenol ]]hydrochloride, other vasopressor agents, or [[cardiopulmonary resuscitation]] (see [[Verapamil hydrochloride injection adverse reactions|ADVERSE REACTIONS: Suggested Treatment of Acute Cardiovascular Adverse Reactions]]). | Clinically significant [[hypotensive ]]reactions or high-degree [[AV block]] should be treated with vasopressor agents or cardiac pacing, respectively. [[Asystole ]]should be handled by the usual measures including [[isoproterenol ]]hydrochloride, other vasopressor agents, or [[cardiopulmonary resuscitation]] (see [[Verapamil hydrochloride injection adverse reactions|ADVERSE REACTIONS: Suggested Treatment of Acute Cardiovascular Adverse Reactions]]).<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = VERAPAMIL HYDROCHLORIDE INJECTION, SOLUTION [CARDINAL HEALTH] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0c27c868-7eae-4b3e-babf-e89404ea27b7#nlm34090-1 | publisher = | date = | accessdate = }}</ref> | ||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = VERAPAMIL HYDROCHLORIDE INJECTION, SOLUTION [CARDINAL HEALTH] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0c27c868-7eae-4b3e-babf-e89404ea27b7#nlm34090-1 | publisher = | date = | accessdate = }}</ref> | |||
Revision as of 23:22, 4 March 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdurahman Khalil, M.D. [2]
OVERDOSAGE
Treatment of overdosage should be supportive and individualized. Beta-adrenergic stimulation and/or parenteral administration of calcium injections may increase calcium ion flux across the slow channel, and have been effectively used in treatment of deliberate overdosage with oral verapamil hydrochloride. Verapamil cannot be removed by hemodialysis.
Clinically significant hypotensive reactions or high-degree AV block should be treated with vasopressor agents or cardiac pacing, respectively. Asystole should be handled by the usual measures including isoproterenol hydrochloride, other vasopressor agents, or cardiopulmonary resuscitation (see ADVERSE REACTIONS: Suggested Treatment of Acute Cardiovascular Adverse Reactions).[1]