Diltiazem hydrochloride injection overdosage: Difference between revisions
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
{{CMG}}; {{AE}} {{AK}} | {{CMG}}; {{AE}} {{AK}} | ||
==OVERDOSAGE== | |||
Overdosage experience is limited. In the event of overdosage or an exaggerated response, appropriate supportive measures should be employed. The following measures may be considered: | |||
'''[[Bradycardia]]:''' Administer atropine (0.6 to 1.0 mg). If there is no response to vagal blockade administer isoproterenol cautiously. | |||
'''High-degree [[AV Block]]:''' Treat as for [[bradycardia ]]above. Fixed high-degree [[AV block]] should be treated with cardiac pacing. | |||
'''[[Cardiac Failure]]:''' Administer [[inotropic ]]agents ([[isoproterenol]], [[dopamine]], or [[dobutamine]]) and [[diuretics]]. | |||
'''[[Hypotension]]:''' [[Vasopressors ]](eg, [[dopamine ]]or [[levarterenol]] bitartrate). | |||
Actual treatment and dosage should depend on the severity of the clinical situation and the judgment and experience of the treating physician. | |||
Diltiazem does not appear to be removed by [[peritoneal ]]or [[hemodialysis]]. Limited data suggest that [[plasmapheresis ]]or [[charcoal ]]hemoperfusion may hasten diltiazem elimination following overdose. | |||
The intravenous LD50's in mice and rats were 60 to 38 mg/kg, respectively. The toxic dose in man is not known.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = DILTIAZEM HYDROCHLORIDE INJECTION [AKORN, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=81c5cf23-a6f8-454a-9575-d01edf49ed34 | publisher = | date = | accessdate = 5 March 2014 }}</ref> | |||
==References== | ==References== | ||
Revision as of 21:38, 5 March 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdurahman Khalil, M.D. [2]
OVERDOSAGE
Overdosage experience is limited. In the event of overdosage or an exaggerated response, appropriate supportive measures should be employed. The following measures may be considered:
Bradycardia: Administer atropine (0.6 to 1.0 mg). If there is no response to vagal blockade administer isoproterenol cautiously.
High-degree AV Block: Treat as for bradycardia above. Fixed high-degree AV block should be treated with cardiac pacing.
Cardiac Failure: Administer inotropic agents (isoproterenol, dopamine, or dobutamine) and diuretics.
Hypotension: Vasopressors (eg, dopamine or levarterenol bitartrate).
Actual treatment and dosage should depend on the severity of the clinical situation and the judgment and experience of the treating physician.
Diltiazem does not appear to be removed by peritoneal or hemodialysis. Limited data suggest that plasmapheresis or charcoal hemoperfusion may hasten diltiazem elimination following overdose.
The intravenous LD50's in mice and rats were 60 to 38 mg/kg, respectively. The toxic dose in man is not known.[1]
References
- ↑ "DILTIAZEM HYDROCHLORIDE INJECTION [AKORN, INC.]". Retrieved 5 March 2014.