Lidocaine (injection): Difference between revisions
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'''| [[Lidocaine indications and usage|Indications and Usage]]''' | '''| [[Lidocaine indications and usage|Indications and Usage]]''' | ||
'''| [[Lidocaine dosage and administration|Dosage and Administration]]''' | '''| [[Lidocaine dosage and administration|Dosage and Administration]]''' | ||
'''| [[Lidocaine contraindications|Contraindications]]''' | '''| [[Lidocaine contraindications|Contraindications]]''' | ||
'''| [[Lidocaine warnings|Warnings and Precautions]]''' | '''| [[Lidocaine warnings|Warnings and Precautions]]''' | ||
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[[Category:Drugs]] | [[Category:Drugs]] | ||
[[Category:Anesthetics]] | [[Category:Anesthetics]] | ||
[[Category:Antiarrhythmic agents]] | [[Category:Antiarrhythmic agents]] | ||
Revision as of 15:33, 11 March 2014
| Lidocaine |
|---|
| XYLOCAINE® FDA Package Insert |
| Indications and Usage |
| Dosage and Administration |
| Contraindications |
| Warnings and Precautions |
| Adverse Reactions |
| Drug Interactions |
| Overdosage |
| Description |
| Clinical Pharmacology |
| Nonclinical Toxicology |
| How Supplied/Storage and Handling |
| Labels and Packages |
| Clinical Trials on Lidocaine |
| ClinicalTrials.gov |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]
For patient information, click here.
Synonyms / Brand Names: XYLOCAINE
Overview
Lidocaine xylocaine, or lignocaine (former BAN is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery.
Category
Anesthetic and Antiarrythmic
FDA Package Insert[1]
| Indications and Usage | Dosage and Administration | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Use in Specific Populations | Overdosage | Description | Clinical Pharmacology | Nonclinical Toxicology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages
Mechanism of Action
Lidocaine alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation.[2] With sufficient blockage the membrane of the postsynaptic neuron will not depolarize and will thus fail to transmit an action potential. This creates the anaesthetic effect by not merely preventing pain signals from propagating to the brain but by stopping them before they begin. Careful titration allows for a high degree of selectivity in the blockage of sensory neurons, whereas higher concentrations will also affect other modalities of neuron signaling.
References
- ↑ "XYLOCAINE (LIDOCAINE HYDROCHLORIDE) INJECTION [ASTRAZENECA LP]".
- ↑ Carterall, William A. (2001). "Sodium Channels and Neuronal Hyperexcitability". Novartis Foundation Symposia. 241: 206. doi:10.1002/0470846682.ch14. ISBN 9780470846681.
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