Fragmin injection/adult indications and dosage: Difference between revisions
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===FDA-Labeled Indications and Dosage (Adult)=== | ===FDA-Labeled Indications and Dosage (Adult)=== | ||
* Abdominal | * Prophylaxis of Venous Thromboembolism Following Abdominal Surgery | ||
: Recommneded dose: 2500 IU SUBQ q24h (starting 1 to 2 hours prior to surgery) for 5 to 10 days. | :: Recommneded dose: 2500 IU SUBQ q24h (starting 1 to 2 hours prior to surgery) for 5 to 10 days. | ||
: High risk: 5000 | :: High risk of thromboembolic complications: 5000 IU SUBQ q24h (starting the evening prior to surgery) for 5 to 10 days OR 2500 IU SUBQ 1 to 2 hours prior to surgery followed by 2500 IU 12 hours later and 5000 IU q24h thereafter for 5 to 10 days | ||
* Acute coronary syndrome, Associated with unstable angina or non-Q-wave myocardial infarction - Myocardial ischemia; Prophylaxis | * Acute coronary syndrome, Associated with unstable angina or non-Q-wave myocardial infarction - Myocardial ischemia; Prophylaxis | ||
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* Deep venous thrombosis, In medical patients with severely restricted mobility due to acute illness; Prophylaxis | * Deep venous thrombosis, In medical patients with severely restricted mobility due to acute illness; Prophylaxis | ||
* Postoperative deep vein thrombosis; Prophylaxis - Total replacement of hip | * Postoperative deep vein thrombosis; Prophylaxis - Total replacement of hip | ||
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! style="height: 30px; line-height: 30px; background: #4479BA; border: 0px; font-size: 100%; text-shadow: 0 -1px 0 rgba(0, 0, 0, 0.5);" align=center | {{fontcolor|#FFF|Infection}} | |||
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| style="padding: 0 5px; font-size: 90%; background: #F5F5F5;" align=center | '''''Preferred Regimen''''' | |||
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| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Drug A]] 50 mg/kg IV q8h''''' | |||
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| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | PLUS | |||
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| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Drug B]] 50 mg/kg IV q8—12h''''' | |||
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| style="padding: 0 5px; font-size: 90%; background: #F5F5F5;" align=center | '''''Alternative Regimen''''' | |||
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| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Drug C]] 50 mg/kg IV q8h''''' | |||
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| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | PLUS | |||
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| style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | ▸ '''''[[Drug D]] 2.5 mg/kg IV q8h''''' <BR> OR <BR> ▸ '''''[[Drug E]] 2.5 mg/kg IV q8h''''' | |||
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===Off-Label Use and Dosage (Adult)=== | ===Off-Label Use and Dosage (Adult)=== | ||
Revision as of 14:22, 19 March 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
FDA-Labeled Indications and Dosage (Adult)
- Prophylaxis of Venous Thromboembolism Following Abdominal Surgery
- Recommneded dose: 2500 IU SUBQ q24h (starting 1 to 2 hours prior to surgery) for 5 to 10 days.
- High risk of thromboembolic complications: 5000 IU SUBQ q24h (starting the evening prior to surgery) for 5 to 10 days OR 2500 IU SUBQ 1 to 2 hours prior to surgery followed by 2500 IU 12 hours later and 5000 IU q24h thereafter for 5 to 10 days
- Acute coronary syndrome, Associated with unstable angina or non-Q-wave myocardial infarction - Myocardial ischemia; Prophylaxis
- Cancer - Venous thromboembolism
- Deep venous thrombosis, In medical patients with severely restricted mobility due to acute illness; Prophylaxis
- Postoperative deep vein thrombosis; Prophylaxis - Total replacement of hip
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