Ticagrelor: Difference between revisions

Ticagrelor
Clinical data
Trade names	Brilinta, Brilique, Possia
Synonyms	AZD-6140
MedlinePlus	a611050
[[Regulation of therapeutic goods \|Template:Engvar data]]	EU EMA: by INN; US FDA: Ticagrelor;
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	Oral
ATC code	B01AC24 (WHO) ;
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	36%
Protein binding	>99.7%
Metabolism	Hepatic (CYP3A4)
Elimination half-life	7 hrs (ticagrelor), 8.5 hrs (active metabolite AR-C124910XX)
Excretion	Biliary
Identifiers
	IUPAC name (1S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino]-5-(propylthio)- 3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol;
CAS Number	274693-27-5 ;
PubChem CID	9871419;
ChemSpider	8047109 ;
UNII	GLH0314RVC;
KEGG	D09017 ;
ChEMBL	ChEMBL398435 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C23H28F2N6O4S
Molar mass	522.567 g/mol
3D model (JSmol)	Interactive image;
	SMILES CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F;
	InChI InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1 ; Key:OEKWJQXRCDYSHL-FNOIDJSQSA-N ;
(what is this?) (verify)

Revision as of 19:20, 19 March 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2]

Synonyms / Brand Names: Brilinta

Ticagrelor (trade name Brilinta in the US, Brilique and Possia in the EU) is a platelet aggregation inhibitor produced by AstraZeneca. The drug was approved for use in the European Union by the European Commission on December 3, 2010.^[1]^[2] The drug was approved by the US Food and Drug Administration on July 20, 2011.^[3]

@@ Line 4: / Line 4: @@
 | verifiedrevid = 443228756
 | IUPAC_name = (1''S'',2''S'',3''R'',5''S'')-3-[7-[(1''R'',2''S'')-2-(3,4-Difluorophenyl)cyclopropylamino]-5-(propylthio)- 3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
-|
+| image = Ticagrelor 01.png
-{|
-| [[File:Ticagrelor_01.png|thumb|600px]]
-|}image = Ticagrelor3.png
 | width = 300
-| image2 = Ticagrelor ball-and-stick animation.gif
 <!--Clinical data-->