Lanoxin tablet/use in specific populations

Lanoxin tablet®
Black Box Warning
Adult Indications and Dosage   FDA-Labeled Use   Off-Label Use
Pediatric Indications and Dosage   FDA-Labeled Use   Off-Label Use
Contraindications
Warnings
Adverse Reactions   Clinical Trials Experience   Postmarketing Experience
Drug Interactions
Use in Specific Populations   Pregnancy   Labor and Delivery   Nursing Mothers   Pediatric Use   Geriatric Use   Gender   Race   Renal Impairment   Hepatic Impairment   Females of Reproductive     Potential and Males   Immunocompromised Patients
Routes and Preparations   Routes   Preparations
IV Compatibility
Overdosage
Pharmacology   Mechanism of Action   Structure   Pharmacodynamics   Pharmacokinetics   Nonclinical Toxicology
Clinical Studies
How Supplied
Images   Drug Images   Package & Label Display Panel
Patient Information   Patient Information from FDA   Patient Information from NLM
Combined Alcohol Use
Look-Alike Drug Names
Drug Shortage Status
Price

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdurahman Khalil, M.D. [2]

Pregnancy

Teratogenic Effects

Pregnancy Category C. Animal reproduction studies have not been conducted with digoxin. It is also not known whether digoxin can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Digoxin should be given to a pregnant woman only if clearly needed.

Nursing Mothers

Studies have shown that digoxin concentrations in the mother’s serum and milk are similar. However, the estimated exposure of a nursing infant to digoxin via breastfeeding will be far below the usual infant maintenance dose. Therefore, this amount should have no pharmacologic effect upon the infant. Nevertheless, caution should be exercised when digoxin is administered to a nursing woman.

Pediatric Use

Newborn infants display considerable variability in their tolerance to digoxin. Premature and immature infants are particularly sensitive to the effects of digoxin, and the dosage of the drug must not only be reduced but must be individualized according to their degree of maturity. Digitalis glycosides can cause poisoning in children due to accidental ingestion.

Geriatric Use

The majority of clinical experience gained with digoxin has been in the elderly population. This experience has not identified differences in response or adverse effects between the elderly and younger patients. However, this drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, which should be based on renal function, and it may be useful to monitor renal function (see DOSAGE AND ADMINISTRATION).