Epidural abscess epidemiology and demographics: Difference between revisions
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===Spinal Epidural Abscess=== | ===Spinal Epidural Abscess=== | ||
The most common type of epidural abscess | The most common type of [[epidural abscess]]. It may occur in patients of all ages, however is more common in those older than 50 years, with studies showing a male predominance of the disease. <ref name="PilkingtonJackson2003">{{cite journal|last1=Pilkington|first1=S. A.|last2=Jackson|first2=S. A.|last3=Gillett|first3=G. R.|title=Spinal epidural empyema|journal=British Journal of Neurosurgery|volume=17|issue=2|year=2003|pages=196–200|issn=0268-8697|doi=10.1080/0268869031000108990}}</ref><ref name="pmid1359381">{{cite journal| author=Darouiche RO, Hamill RJ, Greenberg SB, Weathers SW, Musher DM| title=Bacterial spinal epidural abscess. Review of 43 cases and literature survey. | journal=Medicine (Baltimore) | year= 1992 | volume= 71 | issue= 6 | pages= 369-85 | pmid=1359381 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1359381 }} </ref> The incidence of this disease has doubled during the past two decades, to 0.2-2 cases per 10,000 hospital admissions. Possible explanations for this rise, despite therapy improvements, include: <ref name="Darouiche2006">{{cite journal|last1=Darouiche|first1=Rabih O.|title=Spinal Epidural Abscess|journal=New England Journal of Medicine|volume=355|issue=19|year=2006|pages=2012–2020|issn=0028-4793|doi=10.1056/NEJMra055111}}</ref><ref name="pmid24340840">{{cite journal| author=Strauss I, Carmi-Oren N, Hassner A, Shapiro M, Giladi M, Lidar Z| title=Spinal epidural abscess: in search of reasons for an increased incidence. | journal=Isr Med Assoc J | year= 2013 | volume= 15 | issue= 9 | pages= 493-6 | pmid=24340840 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24340840 }} </ref> | ||
*Increased [[sensitivity]] and accuracy of the diagnostic methods, with the use of [[contrast]] enhanced [[MRI]]; | *Increased [[sensitivity]] and accuracy of the [[diagnostic]] methods, with the use of [[contrast]] enhanced [[MRI]]; | ||
*Immunocompromised and aged population; | *[[Immunocompromised]] and aged population; | ||
*Increased number of neurosurgical and other spinal invasive procedures for [[anaesthesia]] and [[pain management]]; | *Increased number of [[neurosurgery|neurosurgical]] and other [[spinal cord|spinal]] invasive procedures for [[anaesthesia]] and [[pain management]]; | ||
*Increased [[IV]] | *Increased [[IV drug use|IV drug users]]. | ||
In the case of spinal [[catheter]] placement, the [[infection]] might occur at several occasions, namely: | In the case of [[spinal cord|spinal]] [[catheter]] placement, the [[infection]] might occur at several occasions, namely: | ||
*At the time of placement of the [[catheter]]; | *At the time of placement of the [[catheter]]; | ||
*Ascending contamination from the [[skin flora]]; | *Ascending contamination from the [[skin flora]]; | ||
*Injections through the catheter with contaminated syringes; | *Injections through the [[catheter]] with contaminated syringes; | ||
*From [[bacteria]] causing hematogenous seeding of the catheter material. | *From [[bacteria]] causing hematogenous seeding of the catheter material. | ||
According to a meta-analysis published in 2000, "the mortality rates of spinal epidural abscess have not changed significantly over the last 25 years". <ref name="pmid24340840">{{cite journal| author=Strauss I, Carmi-Oren N, Hassner A, Shapiro M, Giladi M, Lidar Z| title=Spinal epidural abscess: in search of reasons for an increased incidence. | journal=Isr Med Assoc J | year= 2013 | volume= 15 | issue= 9 | pages= 493-6 | pmid=24340840 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24340840 }} </ref><ref name="pmid11153548">{{cite journal| author=Reihsaus E, Waldbaur H, Seeling W| title=Spinal epidural abscess: a meta-analysis of 915 patients. | journal=Neurosurg Rev | year= 2000 | volume= 23 | issue= 4 | pages= 175-204; discussion 205 | pmid=11153548 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11153548 }} </ref> | According to a meta-analysis published in 2000, "the mortality rates of [[spinal cord|spinal]] [[epidural abscess]] have not changed significantly over the last 25 years". <ref name="pmid24340840">{{cite journal| author=Strauss I, Carmi-Oren N, Hassner A, Shapiro M, Giladi M, Lidar Z| title=Spinal epidural abscess: in search of reasons for an increased incidence. | journal=Isr Med Assoc J | year= 2013 | volume= 15 | issue= 9 | pages= 493-6 | pmid=24340840 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24340840 }} </ref><ref name="pmid11153548">{{cite journal| author=Reihsaus E, Waldbaur H, Seeling W| title=Spinal epidural abscess: a meta-analysis of 915 patients. | journal=Neurosurg Rev | year= 2000 | volume= 23 | issue= 4 | pages= 175-204; discussion 205 | pmid=11153548 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11153548 }} </ref> | ||
==References== | ==References== | ||
Revision as of 18:24, 30 March 2014
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Epidural abscess Microchapters |
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Epidural abscess epidemiology and demographics On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
An epidural abscess is a rare suppurative infection of the central nervous system, a collection of pus localised in the epidural space, lying outside the dura mater, which accounts for less than 2% of focal CNS infections. [1]. It may occur in two different places: intracranially or in the spinal canal. According to the location of the infection, the epidemiology of each one of the two types of abscesses will differ. This is due to the nature of the location of the disease, but also due to other factors. In either case, in order to prevent severe morbidity and fatal outcomes, accurate diagnosis and prompt therapy should be applied as early as possible.
Epidemiology And Demographics
Intracranial Epidural Abscess
The most rare type of epidural abscess, it accounts for only 1 out of 10 cases of the disease. Despite this fact, it is the 3rd most common common focal intracranial infection, following brain abscess and subdural empyema. Before the arrival of antibiotics, the most common causes of epidural abscess were sinusitis, otitis and mastoiditis. Today it happens most often following neurosurgical procedures and in IV drug users. The cases not related to iatrogenesis occur more commonly in adolescent males, since they are more prone to sinusitis and its complications. This incidence is due to the increase of vascularity of the diploic system and development of frontal sinus between the 7th and 20th year of age, which contributes to the spread of the infection, since the sinus mucosa communicates with the marrow spaces of the frontal bone, as well as with the veins of the dura mater. [2] According to a study of Gallagher et al 15 out of 176 patients with sinusitis, developed some kind of intracranial suppuration as a complication. Of these, 23% developed epidural abscess. [3]
Spinal Epidural Abscess
The most common type of epidural abscess. It may occur in patients of all ages, however is more common in those older than 50 years, with studies showing a male predominance of the disease. [4][5] The incidence of this disease has doubled during the past two decades, to 0.2-2 cases per 10,000 hospital admissions. Possible explanations for this rise, despite therapy improvements, include: [6][7]
- Increased sensitivity and accuracy of the diagnostic methods, with the use of contrast enhanced MRI;
- Immunocompromised and aged population;
- Increased number of neurosurgical and other spinal invasive procedures for anaesthesia and pain management;
- Increased IV drug users.
In the case of spinal catheter placement, the infection might occur at several occasions, namely:
- At the time of placement of the catheter;
- Ascending contamination from the skin flora;
- Injections through the catheter with contaminated syringes;
- From bacteria causing hematogenous seeding of the catheter material.
According to a meta-analysis published in 2000, "the mortality rates of spinal epidural abscess have not changed significantly over the last 25 years". [7][8]
References
- ↑ Longo, Dan L. (Dan Louis) (2012). Harrison's principles of internal medici. New York: McGraw-Hill. ISBN 978-0-07-174889-6.
- ↑ Fountas KN, Duwayri Y, Kapsalaki E, Dimopoulos VG, Johnston KW, Peppard SB; et al. (2004). "Epidural intracranial abscess as a complication of frontal sinusitis: case report and review of the literature". South Med J. 97 (3): 279–82, quiz 283. PMID 15043336.
- ↑ Gallagher RM, Gross CW, Phillips CD (1998). "Suppurative intracranial complications of sinusitis". Laryngoscope. 108 (11 Pt 1): 1635–42. PMID 9818818.
- ↑ Pilkington, S. A.; Jackson, S. A.; Gillett, G. R. (2003). "Spinal epidural empyema". British Journal of Neurosurgery. 17 (2): 196–200. doi:10.1080/0268869031000108990. ISSN 0268-8697.
- ↑ Darouiche RO, Hamill RJ, Greenberg SB, Weathers SW, Musher DM (1992). "Bacterial spinal epidural abscess. Review of 43 cases and literature survey". Medicine (Baltimore). 71 (6): 369–85. PMID 1359381.
- ↑ Darouiche, Rabih O. (2006). "Spinal Epidural Abscess". New England Journal of Medicine. 355 (19): 2012–2020. doi:10.1056/NEJMra055111. ISSN 0028-4793.
- ↑ 7.0 7.1 Strauss I, Carmi-Oren N, Hassner A, Shapiro M, Giladi M, Lidar Z (2013). "Spinal epidural abscess: in search of reasons for an increased incidence". Isr Med Assoc J. 15 (9): 493–6. PMID 24340840.
- ↑ Reihsaus E, Waldbaur H, Seeling W (2000). "Spinal epidural abscess: a meta-analysis of 915 patients". Neurosurg Rev. 23 (4): 175–204, discussion 205. PMID 11153548.