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| __NOTOC__
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| {{Cholestyramine}}
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| {{CMG}}; {{AE}} {{SS}}
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| '''''For patient information about Cholestyramine, click [[Cholestyramine (patient information)|here]].'''''
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| {{SB}} PREVALITE<sup>®</sup>
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| ==Overview==
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| '''Cholestyramine''' or '''colestyramine''' ('''PREVALITE''', '''CHOLESTYRAMINE,CHOLESTYRAMINE LIGHT''') is a [[bile acid sequestrant]], which binds [[bile]] in the [[gastrointestinal tract]] to prevent its reabsorption. It is a strong [[ion exchange resin]], which means that it can exchange its [[chloride]] [[anion]]s with anionic [[bile acid]]s in the gastrointestinal tract and bind them strongly in the resin matrix. The functional group of the anion exchange resin is a [[quaternary ammonium|quaternary]] [[ammonium]] group attached to an inert [[styrene]]-[[divinylbenzene]] [[copolymer]].
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| Cholestyramine removes [[bile acid]]s from the body by forming [[insoluble]] complexes with bile acids in the [[intestine]], which are then excreted in the [[feces]]. When bile acids are excreted, [[blood plasma|plasma]] [[cholesterol]] is converted to bile acid to normalize [[bile acid]] levels. This conversion of [[cholesterol]] into [[bile acid]]s lowers plasma [[cholesterol]] levels.
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| ==Category==
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| Cardiovasuclar Drugs, Bile Acid Sequestrants
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| ==FDA Package Insert==
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| ''' [[Cholestyramine indications and usage|Indications and Usage]]'''
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| '''| [[Cholestyramine dosage and administration|Dosage and Administration]]'''
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| '''| [[Cholestyramine dosage forms and strengths|Dosage Forms and Strengths]]'''
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| '''| [[Cholestyramine contraindications|Contraindications]]'''
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| '''| [[Cholestyramine warnings and precautions|Warnings and Precautions]]'''
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| '''| [[Cholestyramine adverse reactions|Adverse Reactions]]'''
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| '''| [[Cholestyramine drug interactions|Drug Interactions]]'''
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| '''| [[Cholestyramine use in specific populations|Use in Specific Populations]]'''
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| '''| [[Cholestyramine overdosage|Overdosage]]'''
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| '''| [[Cholestyramine description|Description]]'''
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| '''| [[Cholestyramine clinical pharmacology|Clinical Pharmacology]]'''
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| '''| [[Cholestyramine nonclinical toxicology|Nonclinical Toxicology]]'''
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| '''| [[Cholestyramine clinical studies|Clinical Studies]]'''
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| '''| [[Cholestyramine how supplied storage and handling|How Supplied/Storage and Handling]]'''
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| '''| [[Cholestyramine patient counseling information|Patient Counseling Information]]'''
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| '''| [[Cholestyramine labels and packages|Labels and Packages]]'''
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| ==Mechanism of Action==
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| Cholestyramine belongs to the bile acid sequestrants. Bile acid sequestrants are [[polymer]]ic compounds that serve as ion-exchange resins. Bile acid sequestrants exchange [[anion]]s such as [[chloride]] ions for [[bile acid]]s. By doing so, they bind bile acids and sequester them from enterohepatic circulation.
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| Since bile acid sequesterants are large polymeric structures, they are not well-absorbed from the gut into the bloodstream. Thus, bile acid sequestrants, along with any [[bile acid]]s bound to the drug, are excreted via the feces after passage through the gastrointestinal tract.<ref>[http://www.fda.gov/hearthealth/treatments/medications/bileacid.html FDA Heart Health Online - Bile Acid Sequestrants<!-- Bot generated title -->]</ref>
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| ==Publication Resources==
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| <div class="mw-collapsible-content">
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| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} Most Recent Articles on {{#if:{{{1|}}}|{{{1}}}| {{PAGENAME}}}}]
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| [http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}%20AND%20systematic%5Bsb%5D Review Articles on {{PAGENAME}}]
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| [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&db=pubmed&term={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}+AND+%28%28N+Engl+J+Med%5Bta%5D%29+OR+%28Lancet%5Bta%5D%29+OR+%28BMJ%5Bta%5D%29%29 Articles on {{PAGENAME}} in N Eng J Med, Lancet, BMJ]
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| [http://books.google.com/books?ie=UTF-8&oe=utf-8&q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}}&qt_s=Search&sa=N&tab=gp Textbook Information on{{PAGENAME}}]
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| </div></div>
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| ==References==
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| {{Reflist|2}}
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| {{Lipid modifying agents}}
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| [[Category:Hepatology]]
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| [[Category:Bile acid sequestrants]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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