Amoxapine: Difference between revisions
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{{Drugbox| | |||
|IUPAC_name = | |||
| image=Amoxapine.svg | |||
| width=150 | |||
| CAS_number=14028-44-5 | |||
| ATC_prefix=N06 | |||
| ATC_suffix=AA17 | |||
| PubChem=2170 | |||
| DrugBank=APRD00142 | |||
| | C=17 | H=16 | Cl=1 | N=3 | O=1 | |||
| molecular_weight = 313.781 | |||
| bioavailability= ? | |||
| metabolism = Hepatic ([[cytochrome P450|cytochrome P450 system]]) | |||
| elimination_half-life= 8-10 hours (30 hours for major metabolites) | |||
| excretion = Renal | |||
| pregnancy_US = C | |||
| legal_US = Rx-only | |||
| routes_of_administration= Oral | |||
}} | |||
<!-- Commented out because image was deleted: [[Image:AsendinAd.png|thumb|300px|left|Advertisement, 1989.]] --> | |||
'''Amoxapine''' (brand-names '''Asendin'''®, '''Asendis'''®, '''Defanyl'''®, '''Demolox'''®, '''Moxadil'''®) is a [[tricyclic antidepressant]] of the [[dibenzoxazepine]] class. It is used in the treatment of [[clinical depression|depression]], [[panic disorder]]s and [[bipolar disorder]]. | |||
Amoxapine is a strong reuptake inhibitor of [[norepinephrine]] and weak reuptake inhibitor of [[serotonin]]. One of its major metabolites, [[7-hydroxyamoxapine]], has a [[dopamine]] receptor blocking effect. | |||
== See also == | |||
* [[Loxapine]] | |||
==References== | |||
* Mosby Year-Book, Inc. (1995). ''Physician's GenRx: The Complete Drug Reference (5th Ed.)''. Riverside, CT: Denniston Publishing Co. | |||
* Palfai, T. & Jankiewicz, H. (1997). ''Drugs and Human Behavior (2nd Ed.)''. Madison, WI: Brown & Benchmark. | |||
* Hedges, D. & Burchfield, C. (2006). ''Mind, Brain, and Drug: An Introduction to Psychopharmacology.'' Boston, MA: Pearson. | |||
{{Antidepressants}} | |||
[[Category:Norepinephrine reuptake inhibitors]] | |||
[[Category:Tricyclic antidepressants]] | |||
{{psychoactive-stub}} | |||
[[fr:Amoxapine]] | |||
[[ja:アモキサピン]] | |||
{{WikiDoc Help Menu}} | |||
Revision as of 16:30, 13 May 2014
| File:Amoxapine.svg | |
| Clinical data | |
|---|---|
| Pregnancy category |
|
| Routes of administration | Oral |
| ATC code | |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Hepatic (cytochrome P450 system) |
| Elimination half-life | 8-10 hours (30 hours for major metabolites) |
| Excretion | Renal |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C17H16ClN3O |
| Molar mass | 313.781 |
Amoxapine (brand-names Asendin®, Asendis®, Defanyl®, Demolox®, Moxadil®) is a tricyclic antidepressant of the dibenzoxazepine class. It is used in the treatment of depression, panic disorders and bipolar disorder.
Amoxapine is a strong reuptake inhibitor of norepinephrine and weak reuptake inhibitor of serotonin. One of its major metabolites, 7-hydroxyamoxapine, has a dopamine receptor blocking effect.
See also
References
- Mosby Year-Book, Inc. (1995). Physician's GenRx: The Complete Drug Reference (5th Ed.). Riverside, CT: Denniston Publishing Co.
- Palfai, T. & Jankiewicz, H. (1997). Drugs and Human Behavior (2nd Ed.). Madison, WI: Brown & Benchmark.
- Hedges, D. & Burchfield, C. (2006). Mind, Brain, and Drug: An Introduction to Psychopharmacology. Boston, MA: Pearson.
Categories:
- Pages with script errors
- Pages with broken file links
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Chemical articles with unknown parameter in Infobox drug
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Articles containing unverified chemical infoboxes
- Norepinephrine reuptake inhibitors
- Tricyclic antidepressants