Pulmonary hypertension epidemiology and demographics: Difference between revisions
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== Overview == | == Overview == | ||
Pulmonary arterial hypertension has been considered as a disease of young women. The mean age of patients in the U.S. registry was 36 years and the overall female-to-male ratio was 1.7:1.<ref name="Rich-1987">{{Cite journal | last1 = Rich | first1 = S. | last2 = Dantzker | first2 = DR. | last3 = Ayres | first3 = SM. | last4 = Bergofsky | first4 = EH. | last5 = Brundage | first5 = BH. | last6 = Detre | first6 = KM. | last7 = Fishman | first7 = AP. | last8 = Goldring | first8 = RM. | last9 = Groves | first9 = BM. | title = Primary pulmonary hypertension. A national prospective study. | journal = Ann Intern Med | volume = 107 | issue = 2 | pages = 216-23 | month = Aug | year = 1987 | doi = | PMID = 3605900 }}</ref> | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
===Incidence=== | ===Incidence=== | ||
While previously considered a rare disease, the most recent evidence from a French registry suggests that the '''[[incidence]]''' of new cases of pulmonary arterial hypertension is 2-3 cases per million per year. | While previously considered a rare disease, the most recent evidence from a French registry suggests that the '''[[incidence]]''' of new cases of pulmonary arterial hypertension is 2-3 cases per million per year. | ||
===Prevalence=== | ===Prevalence=== | ||
The | |||
The [[prevalence]] is about 15 per million. | |||
===Age=== | ===Age=== | ||
Pulmonary Hypertension usually develops between the ages of 20 and 60, but it can occur at any age. | |||
===Gender=== | ===Gender=== | ||
'''Idiopathic pulmonary hypertension'''(IPAH) which is more prevalent in women (3x more common), was considered the most common type of Pulmonary arterial hypertension in a French registry. | |||
===Genetics=== | ===Genetics=== | ||
'''Familial PAH''' often results from a [[mutation]] in the bone morphogenic protein receptor-2 (BMPR2) and is inherited as an [[autosomal dominant]] disease with incomplete [[penetrance]] and anticipation. | |||
===Incidence of Associated Diseases=== | ===Incidence of Associated Diseases=== | ||
*PAH is also associated with <ref>ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension</ref>: | *PAH is also associated with <ref>ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension</ref>: | ||
#[[Congenital heart disease]](30% of untreated) | #[[Congenital heart disease]](30% of untreated) | ||
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{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[Category:Cardiology]] | [[Category:Cardiology]] | ||
[[Category:Pulmonology]] | [[Category:Pulmonology]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Mature chapter]] | [[Category:Mature chapter]] | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assistant Editor(s)-in-Chief: Ralph Matar
Overview
Pulmonary arterial hypertension has been considered as a disease of young women. The mean age of patients in the U.S. registry was 36 years and the overall female-to-male ratio was 1.7:1.[1]
Epidemiology and Demographics
Incidence
While previously considered a rare disease, the most recent evidence from a French registry suggests that the incidence of new cases of pulmonary arterial hypertension is 2-3 cases per million per year.
Prevalence
The prevalence is about 15 per million.
Age
Pulmonary Hypertension usually develops between the ages of 20 and 60, but it can occur at any age.
Gender
Idiopathic pulmonary hypertension(IPAH) which is more prevalent in women (3x more common), was considered the most common type of Pulmonary arterial hypertension in a French registry.
Genetics
Familial PAH often results from a mutation in the bone morphogenic protein receptor-2 (BMPR2) and is inherited as an autosomal dominant disease with incomplete penetrance and anticipation.
Incidence of Associated Diseases
- PAH is also associated with [2]:
- Congenital heart disease(30% of untreated)
- Connective tissue diseases(12% of patients with scleroderma and upto 21% of patients with rheumatoid arthritis)
- HIV (0.5%)
- Portal hypertension(2-6%)
- Sickle cell disease(20 to 40%).
- Systemic lupus erythematosus(4 to 14%)
- Hemoglobinopathies
- Myeloproliferative disorders.
- Drugs and toxins
- Diet pills such as Fen-Phen produced an annual incidence of 25-50 per million per year.
- Mortality rate is 5.2-5.4 per 100000 and was more common in African-Americans and women.
- The most common cause of hospitilization is heart failure
- The most common cause of death is right ventricular failure and not chronic lower respiratory disease as was once thought.
References
- ↑ Rich, S.; Dantzker, DR.; Ayres, SM.; Bergofsky, EH.; Brundage, BH.; Detre, KM.; Fishman, AP.; Goldring, RM.; Groves, BM. (1987). "Primary pulmonary hypertension. A national prospective study". Ann Intern Med. 107 (2): 216–23. PMID 3605900. Unknown parameter
|month=ignored (help) - ↑ ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension