Perindopril

Perindopril
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: {{SS}] |genericName=Perindopril |aOrAn=an |drugClass=angiotensin converting enzyme inhibitor |indication=hypertension, stable coronary artery disease |hasBlackBoxWarning=Yes |adverseReactions=hyperkalemia, backache, asthenia, dizziness, headache, cough |blackBoxWarningTitle=WARNING: FETAL TOXICITY |blackBoxWarningBody=* When pregnancy is detected, discontinue ACEON as soon as possible. (5.4)

• Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. (5.4)

|fdaLIADAdult=

Hypertension

• Dosing Information

• Use in Uncomplicated Hypertensive Patients:

• Initial dosage: 4 mg PO qd
• Maximun dosage: 16 mg/day PO
• Usually maintaining dosage: 4 mg-8 mg or 2 mg-4 mg PO bid

• Use in Elderly Patients

• Recommended initial dosage: 4 mg PO qd or 2 mg PO bid
• limited dosage: 8 mg/day(Dosages above 8 mg should be administered with careful blood pressure monitoring and dose titration)

Stable Coronary Artery Disease

• Dosing information

• Initial dosage: 4 mg PO qd for 2 weeks
• Maintainance dosage: 8 mg PO qd
• For seniors (age ≥ 70):

• Initial dosage for the 1st week: 2 mg PO qd
• Dosage for the 2nd week: 4 mg PO qd
• Maintaining dosage if tolerated: 8 mg PO qd

Dose Adjustment in Renal Impairment and Dialysis

• Dosing information

• Initial dosage: 2 mg/day
• Maximum dosage: 8 mg/day

|offLabelAdultGuideSupport=Condition 1

• Developed by: (Organization)

• Class of Recommendation: (Class) (Link)

• Strength of Evidence: (Category A/B/C) (Link)

• Dosing Information/Recommendation

• (Dosage)

|offLabelAdultNoGuideSupport=

Diabetes mellitus

• Dosing Information

• 2 mg/day or 4 mg/day

Prophylaxis treatment of Cerebrovascular accident

• Dosing information

• 4 mg/day

Duchenne muscular dystrophy

• Dosing information

• 2-4 mg/day

Heart failure

• Dosing information

|fdaLIADPed=Condition 1

• Dosing Information

(Dosage)

|offLabelPedGuideSupport=Condition 1

• Developed by: (Organization)

• Class of Recommendation: (Class) (Link)

• Strength of Evidence: (Category A/B/C) (Link)

• Dosing Information/Recommendation

• (Dosage)

|offLabelPedNoGuideSupport=Condition 1

• Dosing Information

• There is limited information about Off-Label Non–Guideline-Supported Use of Perindopril in pediatric patients.

|contraindications=* Condition 1

• Condition 2
• Condition 3
• Condition 4
• Condition 5

|warnings=Conidition 1

(Description) |clinicalTrials=Central Nervous System

(list/description of adverse reactions)

Cardiovascular

(list/description of adverse reactions)

Respiratory

(list/description of adverse reactions)

Gastrointestinal

(list/description of adverse reactions)

Hypersensitive Reactions

(list/description of adverse reactions)

Miscellaneous

(list/description of adverse reactions)

|postmarketing=Central Nervous System

(list/description of adverse reactions)

Cardiovascular

(list/description of adverse reactions)

Respiratory

(list/description of adverse reactions)

Gastrointestinal

(list/description of adverse reactions)

Hypersensitive Reactions

(list/description of adverse reactions)

Miscellaneous

(list/description of adverse reactions)

|drugInteractions=* (Drug 1)

• (Description)

• (Drug 2)

• (Description)

• (Drug 3)

• (Description)

|alcohol=Alcohol-Perindopril interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication. }}

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Overview

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Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

There is limited information regarding Perindopril FDA-Labeled Indications and Dosage (Adult) in the drug label.

Off-Label Use and Dosage (Adult)

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding Perindopril FDA-Labeled Indications and Dosage (Pediatric) in the drug label.

Off-Label Use and Dosage (Pediatric)

Contraindications

There is limited information regarding Perindopril Contraindications in the drug label.

Warnings

There is limited information regarding Perindopril Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Perindopril Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Perindopril Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Perindopril Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Perindopril in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Perindopril in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Perindopril during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Perindopril in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Perindopril in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Perindopril in geriatric settings.

Gender

There is no FDA guidance on the use of Perindopril with respect to specific gender populations.

Race

There is no FDA guidance on the use of Perindopril with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Perindopril in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Perindopril in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Perindopril in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Perindopril in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Perindopril Administration in the drug label.

Monitoring

There is limited information regarding Perindopril Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Perindopril and IV administrations.

Overdosage

There is limited information regarding Perindopril overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Perindopril Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Perindopril Mechanism of Action in the drug label.

Structure

There is limited information regarding Perindopril Structure in the drug label.

Pharmacodynamics

There is limited information regarding Perindopril Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Perindopril Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Perindopril Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Perindopril Clinical Studies in the drug label.

How Supplied

There is limited information regarding Perindopril How Supplied in the drug label.

Storage

There is limited information regarding Perindopril Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Perindopril Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Perindopril interaction has not been established. Talk to your doctor regarding the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Perindopril Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Perindopril Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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