Gas gangrene medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
Any significantly massive infection is a medical emergency. In cases of gangrene, the infection is so severe by the time that a diagnosis is made that countering the bacterial load is impossible even with the strongest available [[antibiotic]]s, for example [[gentamycin]] and [[vancomycin]]. [[Antibiotic]]s alone are not effective because they don't penetrate [[ischemic]] [[muscle]]s enough to be effective. Currently, the use of [[penicillin G]] and [[clindamycin]] | Any significantly massive infection is a medical emergency. In cases of gangrene, the infection is so severe by the time that a diagnosis is made that countering the bacterial load is impossible even with the strongest available [[antibiotic]]s, for example [[gentamycin]] and [[vancomycin]]. [[Antibiotic]]s alone are not effective because they don't penetrate [[ischemic]] [[muscle]]s enough to be effective. Currently, the use of [[penicillin G]] and [[clindamycin]] combination remains the most effective and preferred treatment.<ref name="Stevens-2005">{{Cite journal | last1 = Stevens | first1 = DL. | last2 = Bisno | first2 = AL. | last3 = Chambers | first3 = HF. | last4 = Everett | first4 = ED. | last5 = Dellinger | first5 = P. | last6 = Goldstein | first6 = EJ. | last7 = Gorbach | first7 = SL. | last8 = Hirschmann | first8 = JV. | last9 = Kaplan | first9 = EL. | title = Practice guidelines for the diagnosis and management of skin and soft-tissue infections. | journal = Clin Infect Dis | volume = 41 | issue = 10 | pages = 1373-406 | month = Nov | year = 2005 | doi = 10.1086/497143 | PMID = 16231249 }}</ref> | ||
There are two major reasons for this; current antibiotics only prevent replication of bacteria and the production of toxins continues in pre-existing bacteria. Also, the extent of injury caused by the infection may leave the muscle tissues so damaged that the body will never be able to replace the lost structures (including vasculature). | There are two major reasons for this; current antibiotics only prevent replication of bacteria and the production of toxins continues in pre-existing bacteria. Also, the extent of injury caused by the infection may leave the muscle tissues so damaged that the body will never be able to replace the lost structures (including vasculature). | ||
Revision as of 18:51, 19 May 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Any significantly massive infection is a medical emergency. In cases of gangrene, the infection is so severe by the time that a diagnosis is made that countering the bacterial load is impossible even with the strongest available antibiotics, for example gentamycin and vancomycin. Antibiotics alone are not effective because they don't penetrate ischemic muscles enough to be effective. Currently, the use of penicillin G and clindamycin combination remains the most effective and preferred treatment.[1]
There are two major reasons for this; current antibiotics only prevent replication of bacteria and the production of toxins continues in pre-existing bacteria. Also, the extent of injury caused by the infection may leave the muscle tissues so damaged that the body will never be able to replace the lost structures (including vasculature).
Medical Therapy
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References
- ↑ Stevens, DL.; Bisno, AL.; Chambers, HF.; Everett, ED.; Dellinger, P.; Goldstein, EJ.; Gorbach, SL.; Hirschmann, JV.; Kaplan, EL. (2005). "Practice guidelines for the diagnosis and management of skin and soft-tissue infections". Clin Infect Dis. 41 (10): 1373–406. doi:10.1086/497143. PMID 16231249. Unknown parameter
|month=ignored (help)