Polymyalgia rheumatica pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
The underlying pathophysiology of polymyalgia rheumatica (PMR) remains unknown. It has been hypothesized that genetic and environmental factors are implicated, particularly due to the seasonal and geographical differences in the prevalence of this disease. It has also been hypothesized that PMR is associated with infections such as [[parainfluenza virus type 1]], [[mycoplasma pneumoniae]], [[chlamydia pneumoniae]], and [[parvovirus B19]]. In addition, histological exam of synovial biopsies of affected individuals revealed mild synovitis with predominance of [[CD4 T cells]] and [[macrophages]]. | |||
==References== | ==References== | ||
Revision as of 00:06, 1 June 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The underlying pathophysiology of polymyalgia rheumatica (PMR) remains unknown. It has been hypothesized that genetic and environmental factors are implicated, particularly due to the seasonal and geographical differences in the prevalence of this disease. It has also been hypothesized that PMR is associated with infections such as parainfluenza virus type 1, mycoplasma pneumoniae, chlamydia pneumoniae, and parvovirus B19. In addition, histological exam of synovial biopsies of affected individuals revealed mild synovitis with predominance of CD4 T cells and macrophages.