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| __NOTOC__
| | #Redirect [[Polymyalgia rheumatica pathophysiology]] |
| {{Polymyalgia rheumatica}}
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| {{CMG}}
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| ==Overview==
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| ==Causes==
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| The cause of this disorder is unknown; however, studies have shown that during this disorder, the [[white blood cells]] in the body attack the lining of muscle joints, causing inflammation. Recent studies have found that inherited factors also play a role in the probability that an individual will become sick with polymyalgia rheumatica. Several theories have included viral stimulation of the [[immune system]] in genetically susceptible individuals.
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| Manifestation of [[gaintcell arteritis]] as polymyalgia rheumatica is associated with the increased frequency of [[HLA DR4]].<ref name="pmid3259885">{{cite journal |author=Cid MC, Ercilla G, Vilaseca J, ''et al.'' |title=Polymyalgia rheumatica: a syndrome associated with HLA-DR4 antigen |journal=Arthritis Rheum. |volume=31 |issue=5 |pages=678–82 |year=1988 |month=May |pmid=3259885 |doi= |url=}}</ref>.[[PMR]] and [[GCA]] also share the associated sequence polymorphism encoded by the second hypervariable region(HVR) of the [[HLA DRB1 gene]] unlike [[rheumatoid arthritis]] in which the sequence is encoded by third HVR.<ref name="pmid8147928">{{cite journal |author=Weyand CM, Hunder NN, Hicok KC, Hunder GG, Goronzy JJ |title=HLA-DRB1 alleles in polymyalgia rheumatica, giant cell arteritis, and rheumatoid arthritis |journal=Arthritis Rheum. |volume=37 |issue=4 |pages=514–20 |year=1994 |month=April |pmid=8147928 |doi= |url=}}</ref>. Isolated PMR has positive association with TNFb3, independent of HLA DRB1 association.<ref name="pmid10943865">{{cite journal |author=Mattey DL, Hajeer AH, Dababneh A, ''et al.'' |title=Association of giant cell arteritis and polymyalgia rheumatica with different tumor necrosis factor microsatellite polymorphisms |journal=Arthritis Rheum. |volume=43 |issue=8 |pages=1749–55 |year=2000 |month=August |pmid=10943865 |doi=10.1002/1529-0131(200008)43:8<1749::AID-ANR11>3.0.CO;2-K |url=}}</ref>
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| Several [[viruses]] are thought to be linked to polymyalgia rheumatica,including the [[adenovirus]], which causes respiratory infections; the human parvovirus B19, an infection that affects children; and the human parainfluenza virus.
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| ==References==
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| {{reflist|2}}
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| {{WH}}
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| {{WS}}
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| [[Category:Disease]]
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| [[Category:Rheumatology]]
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