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| {| style="border: 2px solid #A8A8A8; font-size: 90%;"
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| ! align="center" style="background: #A8A8A8; padding: 0 10px;" colspan=2 | '''Site of Infection, by Severity or Extent'''
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| ! align="center" style="background: #A8A8A8; padding: 0 10px;" | '''Route of Administration'''
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| ! align="center" style="background: #A8A8A8; padding: 0 10px;" | '''Setting'''
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| ! align="center" style="background: #A8A8A8; padding: 0 10px;" | '''Duration of Therapy'''
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| |-
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| ! style="background: #DCDCDC; padding: 0 10px;" rowspan=3 | '''Soft-tissue only'''
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| | style="background: #DCDCDC; padding: 0 10px; font-weight: bold;" | Mild (Grade 2)
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| | style="background: #DCDCDC; padding: 0 10px;" | Oral (or topical for superficial infections)
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| | style="background: #DCDCDC; padding: 0 10px;" | Outpatient
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| | style="background: #DCDCDC; padding: 0 10px; text-align: center;" | 1–2 wk
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| |-
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| | style="background: #DCDCDC; padding: 0 10px; font-weight: bold;" | Moderate (Grade 3)
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| | style="background: #DCDCDC; padding: 0 10px;" | Oral (or initial parenteral)
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| | style="background: #DCDCDC; padding: 0 10px;" | Outpatient (or inpatient)
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| | style="background: #DCDCDC; padding: 0 10px; text-align: center;" | 1–3 wk
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| |-
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| | style="background: #DCDCDC; padding: 0 10px; font-weight: bold;" | Severe (Grade 4)
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| | style="background: #DCDCDC; padding: 0 10px;" | Initial parenteral, switch to oral when possible
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| | style="background: #DCDCDC; padding: 0 10px;" | Inpatient, then outpatient
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| | style="background: #DCDCDC; padding: 0 10px; text-align: center;" | 2–4 wk
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| |-
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| ! style="background: #F5F5F5; padding: 0 10px;" rowspan=4 | '''Bone or joint'''
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| | style="background: #DCDCDC; padding: 0 10px; font-weight: bold;" | No residual infected tissue
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| | style="background: #F5F5F5; padding: 0 10px;" | Parenteral or oral
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| | style="background: #F5F5F5; padding: 0 10px;" | Inpatient, then outpatient
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| | style="background: #F5F5F5; padding: 0 10px; text-align: center;" | 2–5 d
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| |-
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| | style="background: #DCDCDC; padding: 0 10px; font-weight: bold;" | Residual infected soft tissue
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| | style="background: #F5F5F5; padding: 0 10px;" | Parenteral or oral
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| | style="background: #F5F5F5; padding: 0 10px;" | Inpatient, then outpatient
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| | style="background: #F5F5F5; padding: 0 10px; text-align: center;" | 1–3 wk
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| |-
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| | style="background: #DCDCDC; padding: 0 10px; font-weight: bold;" | Residual infected, viable bone
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| | style="background: #F5F5F5; padding: 0 10px;" | Initial parenteral, switch to oral when possible
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| | style="background: #F5F5F5; padding: 0 10px;" | Inpatient, then outpatient
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| | style="background: #F5F5F5; padding: 0 10px; text-align: center;" | 4–6 wk
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| |-
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| | style="background: #DCDCDC; padding: 0 10px; font-weight: bold;" | Residual dead bone or no surgery
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| | style="background: #F5F5F5; padding: 0 10px;" | Initial parenteral, switch to oral when possible
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| | style="background: #F5F5F5; padding: 0 10px;" | Inpatient, then outpatient
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| | style="background: #F5F5F5; padding: 0 10px; text-align: center;" | ≥3 mo
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| |}
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