Dengue fever future or investigational therapies: Difference between revisions
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==Vaccine development== | ==Vaccine development== | ||
There is no commercially available [[vaccine]] for the dengue [[flavivirus]]. | There is no commercially available [[vaccine]] for the dengue [[flavivirus]]. A number of vaccine candidates are entering phase I or II testing.<ref>{{cite journal|title=Dengue vaccines approach the finish line|author=Edelman R|journal=Clin Infect Dis|volume=45|issue=S1|year=2007|pages=S56–S60|doi=10.1086/518148}}</ref> Sanofi reported that its vaccine was effective in a late stage program. <ref>http://www.nytimes.com/2014/04/29/business/international/sanofi-says-dengue-vaccine-succeeds-in-late-stage-trial.html?_r=0</ref> | ||
==Inhibitors of Viral Replication== | ==Inhibitors of Viral Replication== | ||
Revision as of 16:35, 15 June 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Although there is no commercially available vaccine, there are several ongoing vaccine development programs.
Vaccine development
There is no commercially available vaccine for the dengue flavivirus. A number of vaccine candidates are entering phase I or II testing.[1] Sanofi reported that its vaccine was effective in a late stage program. [2]
Inhibitors of Viral Replication
Emerging evidence suggests that mycophenolic acid and ribivirin inhibit Dengue fever virus replication. Initial experiments showed a fivefold increase in defective viral RNA production by cells treated with each drug.[2] In vivo studies, however, have not yet been done.
References
- ↑ Edelman R (2007). "Dengue vaccines approach the finish line". Clin Infect Dis. 45 (S1): S56&ndash, S60. doi:10.1086/518148.
- ↑ http://www.nytimes.com/2014/04/29/business/international/sanofi-says-dengue-vaccine-succeeds-in-late-stage-trial.html?_r=0