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| {{Atorvastatin}}
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| '''''For patient information, click [[Atorvastatin (patient information)|here]]'''''.
| | ===[[Atorvastatin calcium]]=== |
| | ===[[Amlodipine besylate/Atorvastatin calcium]]=== |
| | ===[[Amlodipine/Atorvastatin]]=== |
| | ===[[Ezetimibe/Atorvastatin]]=== |
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| ==Overview== | | ==Overview== |
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| Atorvastatin is a member of the drug class known as [[statins]], used for lowering blood [[cholesterol]]. It also stabilizes plaque and prevents [[stroke]]s through anti-inflammation and other mechanisms. Like all statins, atorvastatin works by inhibiting [[HMG-CoA reductase]], an enzyme found in liver tissue that plays a key role in production of [[cholesterol]] in the body. | | Sandbox Atorvastatin is a HMG-COA Reductase Inhibitor drug that is FDA approved for the treatment of hyperlipidemia, prevention of cardiovascular disease]]. Adverse reactions includediarrhea, arthralgia, myalgia, urinary tract infectious disease, nasopharyngitis, pain, in extremity. |
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| ==Category== | | ==Category== |
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| Lipid-Lowering Agents, Statins
| | HMG-COA Reductase Inhibitor |
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| ==US Brand Names==
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| Lipitor<sup>®</sup>
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| ==FDA Package Insert==
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| ''' [[Atorvastatin indications and usage|Indications and Usage]]'''
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| '''| [[Atorvastatin dosage and administration|Dosage and Administration]]'''
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| '''| [[Atorvastatin contraindications|Contraindications]]'''
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| '''| [[Atorvastatin warnings|Warnings and Precautions]]'''
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| '''| [[Atorvastatin adverse reactions|Adverse Reactions]]'''
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| '''| [[Atorvastatin overdosage|Overdosage]]'''
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| '''| [[Atorvastatin description|Description]]'''
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| '''| [[Atorvastatin clinical pharmacology|Clinical Pharmacology]]'''
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| '''| [[Atorvastatin clinical studies|Clinical Studies]]'''
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| '''| [[Atorvastatin how supplied storage and handling|How Supplied/Storage and Handling]]'''
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| '''| [[Atorvastatin labels and packages|Labels and Packages]]'''
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| ==Mechanism of Action==
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| Atorvastatin is a selective, competitive inhibitor of [[HMG-CoA reductase]], the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme A to [[mevalonate]], a precursor of [[cholesterol]].
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| In animal models, atorvastatin lowers plasma cholesterol and [[lipoprotein]] levels by inhibiting [[HMG-CoA reductase]] and [[cholesterol]] synthesis in the liver and by increasing the number of hepatic [[LDL receptor]]s on the cell surface to enhance uptake and catabolism of LDL; atorvastatin also reduces [[LDL]] production and the number of [[LDL]] particles.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = LIPITOR (ATORVASTATIN CALCIUM) TABLET, FILM COATED [PARKE-DAVIS DIV OF PFIZER INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c6e131fe-e7df-4876-83f7-9156fc4e8228#nlm34089-3 | publisher = | date = | accessdate = }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Sandbox Atorvastatin is a HMG-COA Reductase Inhibitor drug that is FDA approved for the treatment of hyperlipidemia, prevention of cardiovascular disease]]. Adverse reactions includediarrhea, arthralgia, myalgia, urinary tract infectious disease, nasopharyngitis, pain, in extremity.
Category
HMG-COA Reductase Inhibitor