Vitiligo causes: Difference between revisions
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==Overview== | ==Overview== | ||
Vitiligo is caused by a loss of skin [[melanocytes]]. Although the exact mechanism is not known, at least in some cases, an autoimmune process may play a role. <ref name="pmid12859615">{{cite journal| author=Gauthier Y, Cario Andre M, Taïeb A| title=A critical appraisal of vitiligo etiologic theories. Is melanocyte loss a melanocytorrhagy? | journal=Pigment Cell Res | year= 2003 | volume= 16 | issue= 4 | pages= 322-32 | pmid=12859615 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12859615 }} </ref><ref name="pmid16965269">{{cite journal| author=Dell'anna ML, Picardo M| title=A review and a new hypothesis for non-immunological pathogenetic mechanisms in vitiligo. | journal=Pigment Cell Res | year= 2006 | volume= 19 | issue= 5 | pages= 406-11 | pmid=16965269 | doi=10.1111/j.1600-0749.2006.00333.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16965269 }} </ref> | Vitiligo is caused by a loss of skin [[melanocytes]]. Although the exact mechanism is not known, at least in some cases, an autoimmune process may play a role. <ref name="pmid12859615">{{cite journal| author=Gauthier Y, Cario Andre M, Taïeb A| title=A critical appraisal of vitiligo etiologic theories. Is melanocyte loss a melanocytorrhagy? | journal=Pigment Cell Res | year= 2003 | volume= 16 | issue= 4 | pages= 322-32 | pmid=12859615 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12859615 }} </ref><ref name="pmid16965269">{{cite journal| author=Dell'anna ML, Picardo M| title=A review and a new hypothesis for non-immunological pathogenetic mechanisms in vitiligo. | journal=Pigment Cell Res | year= 2006 | volume= 19 | issue= 5 | pages= 406-11 | pmid=16965269 | doi=10.1111/j.1600-0749.2006.00333.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16965269 }} </ref> | ||
==Associated Conditions== | |||
The fact that vitiligo is more prevalent in patients with certain autoimmune disorders, such as [[Addison's disease]], [[hyperthyroidism]], [[alopecia areata]] and [[pernicious anemia]] supports the hypothesis that vitiligo is due to an autoimmune process,<ref>{{Cite journal | |||
| author = [[Shahla Babaee Nejad]], [[Hamideh Herizchi Qadim]], [[Leila Nazeman]], [[Roohollah Fadaii]] & [[Mohamad Goldust]] | | author = [[Shahla Babaee Nejad]], [[Hamideh Herizchi Qadim]], [[Leila Nazeman]], [[Roohollah Fadaii]] & [[Mohamad Goldust]] | ||
| title = Frequency of autoimmune diseases in those suffering from vitiligo in comparison with normal population | | title = Frequency of autoimmune diseases in those suffering from vitiligo in comparison with normal population | ||
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| month = September | | month = September | ||
| pmid = 24383154 | | pmid = 24383154 | ||
}}</ref> but it should also be recognized that the majority of patients with vitiligo do not have any autoimmune disorder. | }}</ref> but it should also be recognized that the majority of patients with vitiligo do not have any associated autoimmune disorder. | ||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Vitiligo is caused by a loss of skin melanocytes. Although the exact mechanism is not known, at least in some cases, an autoimmune process may play a role. [1][2]
Associated Conditions
The fact that vitiligo is more prevalent in patients with certain autoimmune disorders, such as Addison's disease, hyperthyroidism, alopecia areata and pernicious anemia supports the hypothesis that vitiligo is due to an autoimmune process,[3][4][5] but it should also be recognized that the majority of patients with vitiligo do not have any associated autoimmune disorder.
References
- ↑ Gauthier Y, Cario Andre M, Taïeb A (2003). "A critical appraisal of vitiligo etiologic theories. Is melanocyte loss a melanocytorrhagy?". Pigment Cell Res. 16 (4): 322–32. PMID 12859615.
- ↑ Dell'anna ML, Picardo M (2006). "A review and a new hypothesis for non-immunological pathogenetic mechanisms in vitiligo". Pigment Cell Res. 19 (5): 406–11. doi:10.1111/j.1600-0749.2006.00333.x. PMID 16965269.
- ↑ Shahla Babaee Nejad, Hamideh Herizchi Qadim, Leila Nazeman, Roohollah Fadaii & Mohamad Goldust (2013). "Frequency of autoimmune diseases in those suffering from vitiligo in comparison with normal population". Pakistan journal of biological sciences: PJBS. 16 (12): 570–574. PMID 24494526. Unknown parameter
|month=ignored (help) - ↑ Daniel Holthausen Nunes & Ligia Maria Hademann Esser (2011). "Vitiligo epidemiological profile and the association with thyroid disease". Anais brasileiros de dermatologia. 86 (2): 241–248. PMID 21603806. Unknown parameter
|month=ignored (help) - ↑ Kirsty J. MacLean & Michael J. Tidman (2013). "Alopecia areata: more than skin deep". The Practitioner. 257 (1764): 29–32. PMID 24383154. Unknown parameter
|month=ignored (help)