Vitiligo other diagnostic studies: Difference between revisions
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===Histology=== | ===Histology=== | ||
Histological examination typically shows an absence of [[melanocytes]] in the affected areas of [[skin]]. However, it is possible to sometimes identify degenerating [[melanocytes]] at the borders of the affected areas. In these patients, normal melanocytes may be found in normal skin areas, yet even in these regions changes such as abnormal keratinocytes may be found, showing evidence of vacuolated cytoplasm in basal layers of the cells and granular extracellular materials.<ref>{{cite book | last = Soutor | first = Carol | title = Clinical dermatology | publisher = McGraw-Hill Education/Lange Medical Books | location = New York | year = 2013 | isbn = 978-0-07-177296-9 }}</ref> | Histological examination typically shows an absence of [[melanocytes]] in the affected areas of [[skin]]. However, it is possible to sometimes identify degenerating [[melanocytes]] at the borders of the affected areas. In these patients, normal melanocytes may be found in normal skin areas, yet even in these regions changes such as abnormal keratinocytes may be found, showing evidence of vacuolated cytoplasm in basal layers of the cells and granular extracellular materials.<ref>{{cite book | last = Soutor | first = Carol | title = Clinical dermatology | publisher = McGraw-Hill Education/Lange Medical Books | location = New York | year = 2013 | isbn = 978-0-07-177296-9 }}</ref> In certain situations it is possible to identify [[lymphocytic infiltrates]] on the margin of the [[lesions]], which is consistent with the underlying [[immunologic]] mechanism destroying the [[melanocytes]].<ref>{{cite book | last = Goldsmith | first = Lowell | title = Fitzpatrick's dermatology in general medicine | publisher = McGraw-Hill Medical | location = New York | year = 2012 | isbn = 0071669043 }}</ref> | ||
==References== | ==References== | ||
Revision as of 22:54, 25 June 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Other Diagnosis Studies
Histology
Histological examination typically shows an absence of melanocytes in the affected areas of skin. However, it is possible to sometimes identify degenerating melanocytes at the borders of the affected areas. In these patients, normal melanocytes may be found in normal skin areas, yet even in these regions changes such as abnormal keratinocytes may be found, showing evidence of vacuolated cytoplasm in basal layers of the cells and granular extracellular materials.[1] In certain situations it is possible to identify lymphocytic infiltrates on the margin of the lesions, which is consistent with the underlying immunologic mechanism destroying the melanocytes.[2]
References
- ↑ Soutor, Carol (2013). Clinical dermatology. New York: McGraw-Hill Education/Lange Medical Books. ISBN 978-0-07-177296-9.
- ↑ Goldsmith, Lowell (2012). Fitzpatrick's dermatology in general medicine. New York: McGraw-Hill Medical. ISBN 0071669043.