Vitiligo other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
The cellular mechanism beneath the vitiligo lesion is the destruction of melanocytes, | The [[cellular]] mechanism beneath the [[vitiligo]] [[lesion]] is the destruction of [[melanocytes]] therefore, on an [[histological]] study, it will be noted the absence of [[melanocytes]] and possibly [[lymphocytic]] infiltrates on the periphery of the [[lesions]], consistent with the destruction of [[melanocytes]] by the [[immune system]]. | ||
==Other Diagnosis Studies== | ==Other Diagnosis Studies== | ||
===Histology=== | ===Histology=== | ||
Histological examination typically shows an absence of [[melanocytes]] in the affected areas of [[skin]]. However, it is possible to sometimes identify degenerating [[melanocytes]] at the borders of the affected areas. In these patients, normal melanocytes may be found in normal skin areas, yet even in these regions changes such as abnormal keratinocytes may be found, showing evidence of vacuolated cytoplasm in basal layers of the cells and granular extracellular materials.<ref>{{cite book | last = Soutor | first = Carol | title = Clinical dermatology | publisher = McGraw-Hill Education/Lange Medical Books | location = New York | year = 2013 | isbn = 978-0-07-177296-9 }}</ref> In certain situations it is possible to identify [[lymphocytic]] infiltrates on the margin of the [[lesions]], which is consistent with the underlying [[immunological]] mechanism destroying the [[melanocytes]].<ref>{{cite book | last = Goldsmith | first = Lowell | title = Fitzpatrick's dermatology in general medicine | publisher = McGraw-Hill Medical | location = New York | year = 2012 | isbn = 0071669043 }}</ref> | Histological examination typically shows an absence of [[melanocytes]] in the affected areas of [[skin]]. However, it is possible to sometimes identify degenerating [[melanocytes]] at the borders of the affected areas. In these patients, normal melanocytes may be found in normal skin areas, yet even in these regions changes such as abnormal keratinocytes may be found, showing evidence of vacuolated cytoplasm in basal layers of the cells and granular extracellular materials.<ref>{{cite book | last = Soutor | first = Carol | title = Clinical dermatology | publisher = McGraw-Hill Education/Lange Medical Books | location = New York | year = 2013 | isbn = 978-0-07-177296-9 }}</ref> In certain situations it is possible to identify [[lymphocytic]] infiltrates on the margin of the [[lesions]], which is consistent with the underlying [[immunological]] mechanism destroying the [[melanocytes]].<ref>{{cite book | last = Goldsmith | first = Lowell | title = Fitzpatrick's dermatology in general medicine | publisher = McGraw-Hill Medical | location = New York | year = 2012 | isbn = 0071669043 }}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
The cellular mechanism beneath the vitiligo lesion is the destruction of melanocytes therefore, on an histological study, it will be noted the absence of melanocytes and possibly lymphocytic infiltrates on the periphery of the lesions, consistent with the destruction of melanocytes by the immune system.
Other Diagnosis Studies
Histology
Histological examination typically shows an absence of melanocytes in the affected areas of skin. However, it is possible to sometimes identify degenerating melanocytes at the borders of the affected areas. In these patients, normal melanocytes may be found in normal skin areas, yet even in these regions changes such as abnormal keratinocytes may be found, showing evidence of vacuolated cytoplasm in basal layers of the cells and granular extracellular materials.[1] In certain situations it is possible to identify lymphocytic infiltrates on the margin of the lesions, which is consistent with the underlying immunological mechanism destroying the melanocytes.[2]
References
- ↑ Soutor, Carol (2013). Clinical dermatology. New York: McGraw-Hill Education/Lange Medical Books. ISBN 978-0-07-177296-9.
- ↑ Goldsmith, Lowell (2012). Fitzpatrick's dermatology in general medicine. New York: McGraw-Hill Medical. ISBN 0071669043.