Vitiligo other diagnostic studies: Difference between revisions
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==Other Diagnosis Studies== | ==Other Diagnosis Studies== | ||
===Histology=== | ===Histology=== | ||
[[Histological]] examination typically shows an absence of [[melanocytes]] in the affected areas of the [[skin]]. However, it is possible to sometimes identify degenerating [[melanocytes]] at the borders of the affected areas. In these patients, normal [[melanocytes]] may be found in normal [[skin]] areas yet, even in these regions, changes such as abnormal [[keratinocytes]] may be found, showing evidence of vacuolated [[cytoplasm]] in the basal layers of [[cells]] as well as granular [[extracellular]] materials.<ref>{{cite book | last = Soutor | first = Carol | title = Clinical dermatology | publisher = McGraw-Hill Education/Lange Medical Books | location = New York | year = 2013 | isbn = 978-0-07-177296-9 }}</ref> In certain situations it is possible to identify [[lymphocytic]] infiltrates on the margin of the [[lesions]], which is consistent with the underlying [[immunological]] mechanism, responsible for the destruction of the [[melanocytes]].<ref>{{cite book | last = Goldsmith | first = Lowell | title = Fitzpatrick's dermatology in general medicine | publisher = McGraw-Hill Medical | location = New York | year = 2012 | isbn = 0071669043 }}</ref> | [[Histological]] examination typically shows an absence of [[melanocytes]] in the affected areas of the [[skin]]. However, it is possible to sometimes identify degenerating [[melanocytes]] at the borders of the affected areas. In these patients, normal [[melanocytes]] may be found in normal [[skin]] areas yet, even in these regions, changes such as abnormal [[keratinocytes]] may be found, showing evidence of vacuolated [[cytoplasm]] in the [[Stratum germinativum|basal layers]] of [[cells]] as well as granular [[extracellular]] materials.<ref>{{cite book | last = Soutor | first = Carol | title = Clinical dermatology | publisher = McGraw-Hill Education/Lange Medical Books | location = New York | year = 2013 | isbn = 978-0-07-177296-9 }}</ref> In certain situations it is possible to identify [[lymphocytic]] infiltrates on the margin of the [[lesions]], which is consistent with the underlying [[immunological]] mechanism, responsible for the destruction of the [[melanocytes]].<ref>{{cite book | last = Goldsmith | first = Lowell | title = Fitzpatrick's dermatology in general medicine | publisher = McGraw-Hill Medical | location = New York | year = 2012 | isbn = 0071669043 }}</ref> | ||
==References== | ==References== | ||
Revision as of 17:58, 26 June 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
The cellular mechanism beneath the vitiligo lesion is the destruction of melanocytes. Therefore, on an histological study, it will be noted the absence of melanocytes on the region of the lesion and possibly lymphocytic infiltrates on its periphery, consistent with the destruction of melanocytes by the immune system.
Other Diagnosis Studies
Histology
Histological examination typically shows an absence of melanocytes in the affected areas of the skin. However, it is possible to sometimes identify degenerating melanocytes at the borders of the affected areas. In these patients, normal melanocytes may be found in normal skin areas yet, even in these regions, changes such as abnormal keratinocytes may be found, showing evidence of vacuolated cytoplasm in the basal layers of cells as well as granular extracellular materials.[1] In certain situations it is possible to identify lymphocytic infiltrates on the margin of the lesions, which is consistent with the underlying immunological mechanism, responsible for the destruction of the melanocytes.[2]
References
- ↑ Soutor, Carol (2013). Clinical dermatology. New York: McGraw-Hill Education/Lange Medical Books. ISBN 978-0-07-177296-9.
- ↑ Goldsmith, Lowell (2012). Fitzpatrick's dermatology in general medicine. New York: McGraw-Hill Medical. ISBN 0071669043.