Cinchocaine: Difference between revisions

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{{DrugProjectFormSinglePage
{{drugbox
|authorTag={{chetan}}
| IUPAC_name = 2-butoxy-''N''-(2-diethylaminoethyl) quinoline-4-carboxamide
|genericName=Dibucaine
| image =
|aOrAn=a
| CAS_number = 85-79-0
|drugClass=local anesthetic
| ATC_prefix = C05
|indication=local anesthesia, To relieve pain, pruritus, and inflammation associated with minor skin disorders.
| ATC_suffix = AD04
|adverseReactions=[[dermatologic]]: [[contact dermatitis]], [[photosensitivity]],  [[immunologic]]: [[immune hypersensitivity reaction]]
| ATC_supplemental = {{ATC|D04|AB02}} {{ATC|N01|BB06}} {{ATC|S01|HA06}}
|blackBoxWarningTitle=<b><span style="color:#FF0000;">TITLE</span></b>
| PubChem = 3025
|blackBoxWarningBody=<i><span style="color:#FF0000;">Condition Name:</span></i> (Content)
| DrugBank = APRD00915
|offLabelAdultGuideSupport=There is limited information about <i>Off-Label Guideline-Supported Use</i> of Cinchocaine in adult patients.
| C = 20 | H = 29 | N = 3 | O = 2
|offLabelAdultNoGuideSupport=There is limited information about <i>Off-Label Non–Guideline-Supported Use</i> of Cinchocaine in adult patients.
| molecular_weight = 343.463 g/mol
|offLabelPedGuideSupport=There is limited information about <i>Off-Label Guideline-Supported Use</i> of Cinchocaine in pediatric patients.
| bioavailability =
|offLabelPedNoGuideSupport=There is limited information about <i>Off-Label Non–Guideline-Supported Use</i> of Cinchocaine in pediatric patients.
| protein_bound =  
|alcohol=Alcohol-Cinchocaine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
| metabolism =  
| elimination_half-life =  
| excretion =  
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category =
| legal_AU = <!-- Unscheduled / S2 / S4 / S8 -->
| legal_UK = <!-- GSL / P / POM / CD -->
| legal_US = <!-- OTC / Rx-only -->
| legal_status =
| routes_of_administration =  
}}
}}
==Overview==
'''Cinchocaine''' (or '''Dibucaine''') is an [[amide]] [[local anesthetic]].  It is the active ingredient in some topical hemorrhoid creams.
It is also a component of the [[veterinary]] drug '''Somulose''', used for [[animal euthanasia|euthanasia]] of horses and cattle.
==External links==
* {{cite journal | author = Abdel-Ghani N, Youssef A, Awady M | title = Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry. | journal = Farmaco | volume = 60 | issue = 5 | pages = 419-24 | year = 2005 | id = PMID 15910814}}
* {{cite journal | author = Souto-Padron T, Lima AP, de Oliveira Ribeiro R. | title = Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi. | journal = Parasitol Res | volume = | issue = | pages = | year = 2006 | id = PMID 16612626}}
* {{cite journal | author = Nounou M, El-Khordagui L, Khalafallah N | title = Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles. | journal = Acta Pol Pharm | volume = 62 | issue = 5 | pages = 369-79 | year = | id = PMID 16459486}}
{{Vasoprotectives}}
{{Antipruritics}}
{{local anesthetics}}
[[Category:Local anesthetics]]
{{WikiDoc Help Menu}}
{{WS}}

Revision as of 20:22, 26 June 2014

Cinchocaine
Clinical data
ATC code
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC20H29N3O2
Molar mass343.463 g/mol

Overview

Cinchocaine (or Dibucaine) is an amide local anesthetic. It is the active ingredient in some topical hemorrhoid creams.

It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.

External links

  • Abdel-Ghani N, Youssef A, Awady M (2005). "Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry". Farmaco. 60 (5): 419–24. PMID 15910814.
  • Souto-Padron T, Lima AP, de Oliveira Ribeiro R. (2006). "Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi". Parasitol Res. PMID 16612626.
  • Nounou M, El-Khordagui L, Khalafallah N. "Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles". Acta Pol Pharm. 62 (5): 369–79. PMID 16459486.

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