Leprosy pathophysiology: Difference between revisions
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==Gross Pathology== | ==Gross Pathology== | ||
===Immunologic Reactions=== | ===Immunologic Reactions=== | ||
Systemic [[inflammatory]] reactions may occur before, during or after the [[therapy|treatment]] of leprosy.<ref name="pmid6219136">{{cite journal| author=Modlin RL, Hofman FM, Taylor CR, Rea TH| title=T lymphocyte subsets in the skin lesions of patients with leprosy. | journal=J Am Acad Dermatol | year= 1983 | volume= 8 | issue= 2 | pages= 182-9 | pmid=6219136 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6219136 }} </ref> There are two different types of reactions, which are thought to have different underlying immunologic mechanisms | Systemic [[inflammatory]] reactions may occur before, during or after the [[therapy|treatment]] of leprosy.<ref name="pmid6219136">{{cite journal| author=Modlin RL, Hofman FM, Taylor CR, Rea TH| title=T lymphocyte subsets in the skin lesions of patients with leprosy. | journal=J Am Acad Dermatol | year= 1983 | volume= 8 | issue= 2 | pages= 182-9 | pmid=6219136 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6219136 }} </ref> There are two different types of reactions, which are thought to have different underlying immunologic mechanisms. | ||
====Tipe 1 (T1R) or Reversal Reaction (RR)==== | ====Tipe 1 (T1R) or Reversal Reaction (RR)==== | ||
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====Type 2 (T2R) or Erythema Nodosum Leprosum (ENL)==== | ====Type 2 (T2R) or Erythema Nodosum Leprosum (ENL)==== | ||
* Predominant in lepromatous disease. | * Predominant in lepromatous disease. | ||
* Sudden occurrence of painful nodules. | |||
* Nodules may lead to pustules or ulcers. | |||
* Pustules may discharge pus containing polymorphonuclear cells and degenerating mycobacteria. | |||
* After lesions resolve, brawn skin lesions may remain. | |||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
Revision as of 02:35, 7 July 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Pathogenesis
Genetics
The infection by the mycobacterium leprae and the course of the disease are influenced by certain genetic factors of the host.[1][2] Some single-nucleotide polymorphism have been associated with a higher incidence of leprosy. These include:[1][3][4][5][6]
- Low occurrence of a lymphotoxin-α-producing allele.
- Vitamin D receptor gene.
- TNF-α gene.
- IL-10 gene.
- IFN-γ gene.
- TLR 1 gene.
Another study has also suggested a possible relationship between genetic variants of the NOD2 gene and increased susceptibility to leprosy and the development of type I and II reactions.[7]
Associated Conditions
Gross Pathology
Immunologic Reactions
Systemic inflammatory reactions may occur before, during or after the treatment of leprosy.[8] There are two different types of reactions, which are thought to have different underlying immunologic mechanisms.
Tipe 1 (T1R) or Reversal Reaction (RR)
- Predominant in borderline disease.
- Red patches developing in previous skin lesions, commonly on the face or nerve trunks.
- Erythema of previous skin lesions.
- Inflammation may lead to nerve lesion and paralysis.
- Edema of hands and feet.
- Arthralgia, predominantly of small joints.
- Ulcerated lesions.* Pain or tenderness on lesions.
Type 2 (T2R) or Erythema Nodosum Leprosum (ENL)
- Predominant in lepromatous disease.
- Sudden occurrence of painful nodules.
- Nodules may lead to pustules or ulcers.
- Pustules may discharge pus containing polymorphonuclear cells and degenerating mycobacteria.
- After lesions resolve, brawn skin lesions may remain.
Microscopic Pathology
Histopathology
The manifestations of leprosy depend on the host's immune response towards the mycobacteria. Therefore, tuberculoid and lepromatous patients will show different histopathologic findings:[1][8][9]
- Tuberculoid patients - These patients will show a strong immune response towards the bacteria, with production of IFN-γ and commonly showing a positive lepromin skin test.
- Inflammatory infiltrate with multiple granulomas.
- Granulomas containing giant cells, differentiated macrophages and epithelioid cells.
- Predominance of CD4 cells.
- Low bacterial index.
- Lepromatous patients - These patients will show a weaker immune response towards the bacteria, particularly a weak cell-mediated response.
- Absence of granulomas.
- Straightened skin.
- Predominance of CD8 cells.
- High bacterial index.
References
- ↑ 1.0 1.1 1.2 Bhat, Ramesh Marne; Prakash, Chaitra (2012). "Leprosy: An Overview of Pathophysiology". Interdisciplinary Perspectives on Infectious Diseases. 2012: 1–6. doi:10.1155/2012/181089. ISSN 1687-708X.
- ↑ Alter A, Alcaïs A, Abel L, Schurr E (2008). "Leprosy as a genetic model for susceptibility to common infectious diseases". Hum Genet. 123 (3): 227–35. doi:10.1007/s00439-008-0474-z. PMID 18247059.
- ↑ Alcaïs A, Alter A, Antoni G, Orlova M, Nguyen VT, Singh M; et al. (2007). "Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy". Nat Genet. 39 (4): 517–22. doi:10.1038/ng2000. PMID 17353895.
- ↑ Mira MT, Alcais A, di Pietrantonio T, Thuc NV, Phuong MC, Abel L; et al. (2003). "Segregation of HLA/TNF region is linked to leprosy clinical spectrum in families displaying mixed leprosy subtypes". Genes Immun. 4 (1): 67–73. doi:10.1038/sj.gene.6363911. PMID 12595904.
- ↑ Correa-Oliveira, Rodrigo; Misch, Elizabeth A.; Macdonald, Murdo; Ranjit, Chaman; Sapkota, Bishwa R.; Wells, Richard D.; Siddiqui, M. Ruby; Kaplan, Gilla; Hawn, Thomas R. (2008). "Human TLR1 Deficiency Is Associated with Impaired Mycobacterial Signaling and Protection from Leprosy Reversal Reaction". PLoS Neglected Tropical Diseases. 2 (5): e231. doi:10.1371/journal.pntd.0000231. ISSN 1935-2735.
- ↑ Cardoso CC, Pereira AC, Brito-de-Souza VN, Dias-Baptista IM, Maniero VC, Venturini J; et al. (2010). "IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians". Hum Genet. 128 (5): 481–90. doi:10.1007/s00439-010-0872-x. PMID 20714752.
- ↑ Berrington WR, Macdonald M, Khadge S, Sapkota BR, Janer M, Hagge DA; et al. (2010). "Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states". J Infect Dis. 201 (9): 1422–35. doi:10.1086/651559. PMC 2853728. PMID 20350193.
- ↑ 8.0 8.1 Modlin RL, Hofman FM, Taylor CR, Rea TH (1983). "T lymphocyte subsets in the skin lesions of patients with leprosy". J Am Acad Dermatol. 8 (2): 182–9. PMID 6219136.
- ↑ Wallach D, Flageul B, Bach MA, Cottenot F (1984). "The cellular content of dermal leprous granulomas: an immuno-histological approach". Int J Lepr Other Mycobact Dis. 52 (3): 318–26. PMID 6332791.