Lidocaine (injection): Difference between revisions

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__NOTOC__
{{DrugProjectFormSinglePage
|authorTag=


{{Lidocaine}}
Gerald Chi


{{CMG}}; {{AE}} {{AZ}}
<!--Overview-->


'''''For patient information about Lidocaine Transdermal Patch, click <u>[[Lidocaine (patient information)|here]]'''''</u>.
|genericName=


'''''For patient information about Lidocaine Viscous (lye' doe kane), click <u>[[Lidocaine (patient information)|here]]'''''</u>.


{{SB}} XYLOCAINE


==Overview==
|aOrAn=
'''Lidocaine''' '''xylocaine''', or '''lignocaine''' (former [[British Approved Name|BAN]] is a common [[local anesthetic]] and [[antiarrhythmic agent|antiarrhythmic]] drug. Lidocaine is used [[topical]]ly to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery.


==Category==
a
Anesthetic and Antiarrythmic


==FDA Package Insert<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = XYLOCAINE (LIDOCAINE HYDROCHLORIDE) INJECTION [ASTRAZENECA LP] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=723c8e7e-75eb-4119-4ab0-ab52955869f7#nlm34067-9 | publisher =  | date =  | accessdate = }}</ref>==
|drugClass=


'''| [[Lidocaine indications and usage|Indications and Usage]]'''
'''| [[Lidocaine dosage and administration|Dosage and Administration]]'''
'''| [[Lidocaine contraindications|Contraindications]]'''
'''| [[Lidocaine warnings|Warnings and Precautions]]'''
'''| [[Lidocaine adverse reactions|Adverse Reactions]]'''
'''| [[Lidocaine drug interactions|Drug Interactions]]'''
'''| [[Lidocaine use in specific populations|Use in Specific Populations]]'''
'''| [[Lidocaine overdosage|Overdosage]]'''
'''| [[Lidocaine description|Description]]'''
'''| [[Lidocaine clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Lidocaine nonclinical toxicology|Nonclinical Toxicology]]'''
'''| [[Lidocaine clinical studies|Clinical Studies]]'''
'''| [[Lidocaine how supplied storage and handling|How Supplied/Storage and Handling]]'''
'''| [[Lidocaine patient counseling information|Patient Counseling Information]]'''
'''| [[Lidocaine labels and packages|Labels and Packages]]'''


==Mechanism of Action==
Lidocaine alters signal conduction in [[neuron]]s by blocking the fast [[sodium channel|voltage gated sodium (Na<sup>+</sup>) channels]] in the neuronal cell membrane that are responsible for signal propagation.<ref name="novartis">{{cite journal |doi=10.1002/0470846682.ch14 |chapter=Molecular Mechanisms of Gating and Drug Block of Sodium Channels |title=Sodium Channels and Neuronal Hyperexcitability |series=Novartis Foundation Symposia |year=2001 |last1=Carterall |first1=William A. |isbn=9780470846681 |volume=241 |pages=206}}</ref> With sufficient blockage the membrane of the postsynaptic neuron will not depolarize and will thus fail to transmit an [[action potential]]. This creates the [[anaesthetic]] effect by not merely preventing pain signals from propagating to the brain but by stopping them before they begin. Careful titration allows for a high degree of selectivity in the blockage of sensory neurons, whereas higher concentrations will also affect other modalities of neuron signaling.


==References==
|indication=


{{Reflist|2}}


[[Category:Drugs]]
 
[[Category:Anesthetics]]
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[[Category:Cardiovascular Drugs]]
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Revision as of 19:54, 10 July 2014

Lidocaine (injection)
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gerald Chi

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Black Box Warning

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Lidocaine (injection) is a that is FDA approved for the {{{indicationType}}} of . There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Lidocaine (injection) in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Lidocaine (injection) in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Lidocaine (injection) in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Lidocaine (injection) in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Lidocaine (injection) in pediatric patients.

Contraindications

  • Condition1

Warnings

Title
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Lidocaine (injection) in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Lidocaine (injection) in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Lidocaine (injection) in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Lidocaine (injection) during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Lidocaine (injection) with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Lidocaine (injection) with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Lidocaine (injection) with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Lidocaine (injection) with respect to specific gender populations.

Race

There is no FDA guidance on the use of Lidocaine (injection) with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Lidocaine (injection) in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Lidocaine (injection) in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Lidocaine (injection) in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Lidocaine (injection) in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Lidocaine (injection) in the drug label.

Condition1
  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Lidocaine (injection) in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Lidocaine (injection) in the drug label.

Pharmacology

There is limited information regarding Lidocaine (injection) Pharmacology in the drug label.

Mechanism of Action

Structure

File:Lidocaine (injection)01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Lidocaine (injection) in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Lidocaine (injection) in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Lidocaine (injection) in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Lidocaine (injection) in the drug label.

Condition1
  • Description

How Supplied

Storage

There is limited information regarding Lidocaine (injection) Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Lidocaine (injection) |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Lidocaine (injection) |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Lidocaine (injection) in the drug label.

Precautions with Alcohol

  • Alcohol-Lidocaine (injection) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)


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