Smallpox future or investigational therapies: Difference between revisions
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==Future or Investigational Therapies== | ==Future or Investigational Therapies== | ||
Ever since the eradication of the smallpox virus, many antiviral drugs have been | Ever since the eradication of the [[smallpox virus]], many [[antiviral drugs]] have been studied against orthopox [[viruses]] in general, including:<ref name="MooreSeward2006">{{cite journal|last1=Moore|first1=Zack S|last2=Seward|first2=Jane F|last3=Lane|first3=J Michael|title=Smallpox|journal=The Lancet|volume=367|issue=9508|year=2006|pages=425–435|issn=01406736|doi=10.1016/S0140-6736(06)68143-9}}</ref> | ||
* '''Cidofovir''' | * '''Cidofovir''' | ||
:* Inhibitor of the viral DNA polymerase | :* Inhibitor of the [[viral]] [[DNA polymerase]] | ||
:* Treatment of other DNA viruses | :* Treatment of other [[DNA viruses]] | ||
:* Investigational drug for the treatment of potential adverse effect following smallpox vaccination | :* Investigational drug for the treatment of potential adverse effect following [[smallpox]] [[vaccination]] | ||
:* Available in the IV form, with severe nephrotoxicity | :* Available in the [[IV]] form, with severe [[nephrotoxicity]] | ||
:* New formulations are being studied | :* New formulations are being studied | ||
Revision as of 04:31, 11 July 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Future or Investigational Therapies
Ever since the eradication of the smallpox virus, many antiviral drugs have been studied against orthopox viruses in general, including:[1]
- Cidofovir
- Inhibitor of the viral DNA polymerase
- Treatment of other DNA viruses
- Investigational drug for the treatment of potential adverse effect following smallpox vaccination
- Available in the IV form, with severe nephrotoxicity
- New formulations are being studied
- Poxvirus protease inhibitors
- Currently being studied
- Compounds to target host's intracellular pathways
- Currently being studied
References
- ↑ Moore, Zack S; Seward, Jane F; Lane, J Michael (2006). "Smallpox". The Lancet. 367 (9508): 425–435. doi:10.1016/S0140-6736(06)68143-9. ISSN 0140-6736.