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Labetalol
LABETALOL tablet^® FDA Package Insert
Indications and Usage
Dosage and Administration
Dosage Forms and Strengths
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
LABETALOL injection^® FDA Package Insert
Indications and Usage
Dosage and Administration
Dosage Forms and Strengths
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
Clinical Trials on Labetalol
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]

For patient information about Labetalol oral, click here

Synonyms / Brand Names: TRANDATE^®（discontinued）NORMOZIDE^®（discontinued）NORMODYNE^®（discontinued）

Overview

Labetalol (Normodyne, Trandate, fixed combination with hydrochlorothiazide: Normozyde) is an alpha-1 andbeta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance.

It has a particular indication in the treatment of pregnancy-induced hypertension.

FDA Package Insert

Labetalol Hydrochloride injection

Labetalol Hydrochloride tablet

Mechanism of Action

The mechanism of action of the antihypertensive response of Labetalol has not been definitively established. Possible factors that may be involved include: (1) decreased heart rate, (2) decreased myocardial contractility, (3) diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers, (4) suppression of renin activity and (5) vasodilation and decreased peripheral vascular resistance.

References

Template:WikiDoc Sources

@@ Line 1: / Line 1: @@
 __NOTOC__
-{{Bisoprolol}}
+{{Labetalol}}
 {{CMG}}; {{AE}} {{SS}}
-'''''For patient information about Bisoprolol, click [[Bisoprolol (patient information)|here]].'''''
+'''''For patient information about Labetalol oral, click [[Labetalol (patient information)|here]]'''''
-{{SB}} ZEBETA<sup>®</sup>
+{{SB}} TRANDATE<sup>®</sup>（discontinued）NORMOZIDE<sup>®</sup>（discontinued）NORMODYNE<sup>®</sup>（discontinued）
 ==Overview==
+'''Labetalol''' ('''Normodyne''', '''Trandate''', fixed combination with [[hydrochlorothiazide]]: '''Normozyde''') is an [[alpha blocker|alpha-1]] and[[beta blocker|beta adrenergic blocker]] used to treat [[hypertension|high blood pressure]].  It works by blocking these adrenergic receptors, which slows sinus [[heart]] rate, decreases peripheral vascular resistance.
-'''Bisoprolol''' is a drug belonging to the group of [[beta blocker]]s, a class of drugs used primarily in [[cardiovascular disease]]s. More specifically, it is a selective type β1 [[adrenergic receptor]] blocker <ref>[http://www.fass.se/LIF/produktfakta/artikel_produkt.jsp?NplID=20040326000029&DocTypeID=7&UserTypeID=2 FASS (Swedish official drug catalog) (labeling as "Selektiv beta1-blockerare" = selective beta1-blocker)]</ref>.
+It has a particular indication in the treatment of [[pregnancy-induced hypertension]].
 ==Category==
+Cardiovascular Drugs:Beta blockers
+==FDA Package Insert==
+===Labetalol Hydrochloride injection===
-Beta blockers
+'''| [[Labetalol injection indications and usage|Indications and Usage]]'''
+'''| [[Labetalol injection dosage and administration|Dosage and Administration]]'''
+'''| [[Labetalol injection dosage forms and strengths|Dosage Forms and Strengths]]'''
+'''| [[Labetalol injection contraindications|Contraindications]]'''
+'''| [[Labetalol injection warnings and precautions|Warnings and Precautions]]'''
+'''| [[Labetalol injection adverse reactions|Adverse Reactions]]'''
+'''| [[Labetalol injection drug interactions|Drug Interactions]]'''
+'''| [[Labetalol injection use in specific populations|Use in Specific Populations]]'''
+'''| [[Labetalol injection overdosage|Overdosage]]'''
+'''| [[Labetalol injection description|Description]]'''
+'''| [[Labetalol injection clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[Labetalol injection nonclinical toxicology|Nonclinical Toxicology]]'''
+'''| [[Labetalol injection how supplied storage and handling|How Supplied/Storage and Handling]]'''
+'''| [[Labetalol injection patient counseling information|Patient Counseling Information]]'''
+'''| [[Labetalol injection labels and packages|Labels and Packages]]'''
-==FDA Package Insert==
+===Labetalol Hydrochloride tablet===
-====ZEBETA (bisoprolol fumarate) tablet====
-'''  [[Bisoprolol indications and usage|Indications and Usage]]'''
+'''| [[Labetalol tablet indications and usage|Indications and Usage]]'''
-'''| [[Bisoprolol dosage and administration|Dosage and Administration]]'''
+'''| [[Labetalol tablet dosage and administration|Dosage and Administration]]'''
-'''| [[Bisoprolol contraindications|Contraindications]]'''
+'''| [[Labetalol tablet dosage forms and strengths|Dosage Forms and Strengths]]'''
-'''| [[Bisoprolol warnings and precautions|Warnings and Precautions]]'''
+'''| [[Labetalol tablet contraindications|Contraindications]]'''
-'''| [[Bisoprolol adverse reactions|Adverse Reactions]]'''
+'''| [[Labetalol tablet warnings and precautions|Warnings and Precautions]]'''
-'''| [[Bisoprolol drug interactions|Drug Interactions]]'''
+'''| [[Labetalol tablet adverse reactions|Adverse Reactions]]'''
-'''| [[Bisoprolol use in specific populations|Use in Specific Populations]]'''
+'''| [[Labetalol tablet drug interactions|Drug Interactions]]'''
-'''| [[Bisoprolol overdosage|Overdosage]]'''
+'''| [[Labetalol tablet use in specific populations|Use in Specific Populations]]'''
-'''| [[Bisoprolol description|Description]]'''
+'''| [[Labetalol tablet overdosage|Overdosage]]'''
-'''| [[Bisoprolol clinical pharmacology|Clinical Pharmacology]]'''
+'''| [[Labetalol tablet description|Description]]'''
-'''| [[Bisoprolol nonclinical toxicology|Nonclinical Toxicology]]'''
+'''| [[Labetalol tablet clinical pharmacology|Clinical Pharmacology]]'''
-'''| [[Bisoprolol clinical studies|Clinical Studies]]'''
+'''| [[Labetalol tablet nonclinical toxicology|Nonclinical Toxicology]]'''
-'''| [[Bisoprolol how supplied storage and handling|How Supplied/Storage and Handling]]'''
+'''| [[Labetalol tablet how supplied storage and handling|How Supplied/Storage and Handling]]'''
-'''| [[Bisoprolol patient counseling information|Patient Counseling Information]]'''
+'''| [[Labetalol tablet patient counseling information|Patient Counseling Information]]'''
-'''| [[Bisoprolol labels and packages|Labels and Packages]]'''
+'''| [[Labetalol tablet labels and packages|Labels and Packages]]'''
 ==Mechanism of Action==
+The mechanism of action of the [[antihypertensive]] response of Labetalol has not been definitively established. Possible factors that may be involved include: (1) decreased heart rate, (2) decreased myocardial contractility, (3) diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers, (4) suppression of renin activity and (5) vasodilation and decreased peripheral vascular resistance.
-The mechanism of action of its antihypertensive effects has not been completely established. Factors which may be involved include:
-*Decreased cardiac output,
-*Inhibition of renin release by the kidneys,
-*Diminution of tonic sympathetic outflow from the vasomotor centers in the brain.
 ==References==
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 [[Category:Beta blockers]]
 [[Category:Cardiovascular Drugs]]
 [[Category:Drugs]]
+{{WikiDoc Help Menu}}
+{{WikiDoc Sources}}