Smallpox future or investigational therapies: Difference between revisions
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Ever since the eradication of the [[smallpox virus]], many [[antiviral drugs]] have been studied against orthopox [[viruses]] in general, including:<ref name="MooreSeward2006">{{cite journal|last1=Moore|first1=Zack S|last2=Seward|first2=Jane F|last3=Lane|first3=J Michael|title=Smallpox|journal=The Lancet|volume=367|issue=9508|year=2006|pages=425–435|issn=01406736|doi=10.1016/S0140-6736(06)68143-9}}</ref> | Ever since the eradication of the [[smallpox virus]], many [[antiviral drugs]] have been studied against orthopox [[viruses]] in general, including:<ref name="MooreSeward2006">{{cite journal|last1=Moore|first1=Zack S|last2=Seward|first2=Jane F|last3=Lane|first3=J Michael|title=Smallpox|journal=The Lancet|volume=367|issue=9508|year=2006|pages=425–435|issn=01406736|doi=10.1016/S0140-6736(06)68143-9}}</ref> | ||
* '''Cidofovir''' | * '''Cidofovir''' | ||
:* Inhibitor of the [[viral]] [[DNA polymerase]] | :* Inhibitor of the [[viral]] [[DNA polymerase]]<ref name="pmid12615302">{{cite journal| author=Smee DF, Sidwell RW| title=A review of compounds exhibiting anti-orthopoxvirus activity in animal models. | journal=Antiviral Res | year= 2003 | volume= 57 | issue= 1-2 | pages= 41-52 | pmid=12615302 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12615302 }} </ref> | ||
:* Treatment of other [[DNA viruses]] | :* Treatment of other [[DNA viruses]] | ||
:* Investigational drug for the treatment of potential adverse effect following [[smallpox]] [[vaccination]] | :* Investigational drug for the treatment of potential adverse effect following [[smallpox]] [[vaccination]] | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Future or Investigational Therapies
Ever since the eradication of the smallpox virus, many antiviral drugs have been studied against orthopox viruses in general, including:[1]
- Cidofovir
- Inhibitor of the viral DNA polymerase[2]
- Treatment of other DNA viruses
- Investigational drug for the treatment of potential adverse effect following smallpox vaccination
- Available in the IV form, with severe nephrotoxicity
- New formulations are being studied
- Poxvirus protease inhibitors
- Currently being studied
- Compounds to target host's intracellular pathways
- Currently being studied
References
- ↑ Moore, Zack S; Seward, Jane F; Lane, J Michael (2006). "Smallpox". The Lancet. 367 (9508): 425–435. doi:10.1016/S0140-6736(06)68143-9. ISSN 0140-6736.
- ↑ Smee DF, Sidwell RW (2003). "A review of compounds exhibiting anti-orthopoxvirus activity in animal models". Antiviral Res. 57 (1–2): 41–52. PMID 12615302.