Smallpox future or investigational therapies: Difference between revisions
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* '''Poxvirus protease inhibitors''' | * '''Poxvirus protease inhibitors''' | ||
:* Currently being studied | :* Currently being studied<ref name="pmid14972516">{{cite journal| author=Buller RM, Owens G, Schriewer J, Melman L, Beadle JR, Hostetler KY| title=Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model. | journal=Virology | year= 2004 | volume= 318 | issue= 2 | pages= 474-81 | pmid=14972516 | doi=10.1016/j.virol.2003.11.015 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14972516 }} </ref><ref name="pmid14742188">{{cite journal| author=Quenelle DC, Collins DJ, Wan WB, Beadle JR, Hostetler KY, Kern ER| title=Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir. | journal=Antimicrob Agents Chemother | year= 2004 | volume= 48 | issue= 2 | pages= 404-12 | pmid=14742188 | doi= | pmc=PMC321539 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14742188 }} </ref><ref name="pmid15283988">{{cite journal| author=Painter GR, Hostetler KY| title=Design and development of oral drugs for the prophylaxis and treatment of smallpox infection. | journal=Trends Biotechnol | year= 2004 | volume= 22 | issue= 8 | pages= 423-7 | pmid=15283988 | doi=10.1016/j.tibtech.2004.06.008 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15283988 }} </ref> | ||
* Compounds to target host's intracellular pathways | * Compounds to target host's intracellular pathways | ||
Revision as of 15:27, 11 July 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Future or Investigational Therapies
Ever since the eradication of the smallpox virus, many antiviral drugs have been studied against orthopox viruses in general, including:[1]
- Cidofovir
- Inhibitor of the viral DNA polymerase[2]
- Treatment of other DNA viruses
- Investigational drug for the treatment of potential adverse effect following smallpox vaccination
- Available in the IV form, with severe nephrotoxicity
- New formulations are being studied
- Poxvirus protease inhibitors
- Compounds to target host's intracellular pathways
- Currently being studied
References
- ↑ Moore, Zack S; Seward, Jane F; Lane, J Michael (2006). "Smallpox". The Lancet. 367 (9508): 425–435. doi:10.1016/S0140-6736(06)68143-9. ISSN 0140-6736.
- ↑ Smee DF, Sidwell RW (2003). "A review of compounds exhibiting anti-orthopoxvirus activity in animal models". Antiviral Res. 57 (1–2): 41–52. PMID 12615302.
- ↑ Buller RM, Owens G, Schriewer J, Melman L, Beadle JR, Hostetler KY (2004). "Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model". Virology. 318 (2): 474–81. doi:10.1016/j.virol.2003.11.015. PMID 14972516.
- ↑ Quenelle DC, Collins DJ, Wan WB, Beadle JR, Hostetler KY, Kern ER (2004). "Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir". Antimicrob Agents Chemother. 48 (2): 404–12. PMC 321539. PMID 14742188.
- ↑ Painter GR, Hostetler KY (2004). "Design and development of oral drugs for the prophylaxis and treatment of smallpox infection". Trends Biotechnol. 22 (8): 423–7. doi:10.1016/j.tibtech.2004.06.008. PMID 15283988.