WBR0141: Difference between revisions
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|MainCategory=Immunology | |MainCategory=Immunology | ||
|SubCategory=General Principles | |SubCategory=General Principles | ||
|MainCategory=Immunology | |||
|MainCategory=Immunology | |MainCategory=Immunology | ||
|MainCategory=Immunology | |MainCategory=Immunology | ||
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|MainCategory=Immunology | |MainCategory=Immunology | ||
|SubCategory=General Principles | |SubCategory=General Principles | ||
|Prompt=Neutrophils are critically involved in the process of inflammation. The sequence of events in the recruitment of neutrophils from the vessel lumen to the | |Prompt=Neutrophils are critically involved in the process of inflammation. The sequence of events in the recruitment of neutrophils from the vessel lumen to the stromal compartment is called extravasation, and can be divided into four steps. Which of the following signaling mediators is involved in the migration of neutrophils across endothelial cells? | ||
|Explanation=[[PECAM-1]] is involved in diapedesis, which is the migration of the neutrophils across the endothelial cells. | |||
|Explanation= [[PECAM-1]] is involved in diapedesis, which is the migration of the neutrophils across the endothelial cells. | |||
The four steps of [[extravasation]] are: | The four steps of [[extravasation]] are: | ||
# Margination and rolling | # Margination and rolling | ||
# Tight-binding | # Tight-binding | ||
# Diapedsis | # Diapedsis: the migration of the neutrophils across the endothelial cells. | ||
# Migration | # Migration: the movement of neutrophils through the interstitium to the location of the infection, guided by C5a, IL-8, kallikrein, and platelet-activation factors, the signalling mediators. | ||
|AnswerA=E selectin and P selectin | |AnswerA=E selectin and P selectin | ||
|AnswerAExp=[[E selectin]] and P selectin are involved in the rolling phase of extravasation. | |AnswerAExp=[[E selectin]] and P selectin are involved in the rolling phase of extravasation. | ||
Line 40: | Line 38: | ||
|AnswerE=Interleukin 8 | |AnswerE=Interleukin 8 | ||
|AnswerEExp=[[Interleukin]] 8 is involved in the migration of [[leukocytes]] through the interstitium towards the site of [[inflammation]]. | |AnswerEExp=[[Interleukin]] 8 is involved in the migration of [[leukocytes]] through the interstitium towards the site of [[inflammation]]. | ||
|EducationalObjectives=[[PECAM 1]] is involved in diapedesis, which is the migration of the leukocytes across endothelial cells. | |||
|References= First Aid 2014 page 224 | |References=First Aid 2014 page 224 | ||
|RightAnswer=C | |RightAnswer=C | ||
|WBRKeyword=Inflammation, Diapedesis, Leukocyte, Leukocyte adhesion, Endothelium, Endothelial cell | |WBRKeyword=Inflammation, Diapedesis, Leukocyte, Leukocyte adhesion, Endothelium, Endothelial cell | ||
|Approved= Yes | |Approved=Yes | ||
}} | }} |
Revision as of 15:08, 12 July 2014
Author | [[PageAuthor::Rim Halaby, M.D. [1], Alison Leibowitz [2] (Reviewed by Alison Leibowitz)]] |
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Exam Type | ExamType::USMLE Step 1 |
Main Category | MainCategory::Immunology |
Sub Category | SubCategory::General Principles |
Prompt | [[Prompt::Neutrophils are critically involved in the process of inflammation. The sequence of events in the recruitment of neutrophils from the vessel lumen to the stromal compartment is called extravasation, and can be divided into four steps. Which of the following signaling mediators is involved in the migration of neutrophils across endothelial cells?]] |
Answer A | AnswerA::E selectin and P selectin |
Answer A Explanation | [[AnswerAExp::E selectin and P selectin are involved in the rolling phase of extravasation.]] |
Answer B | AnswerB::ICAM 1 |
Answer B Explanation | [[AnswerBExp::ICAM-1 is involved in the tight binding of neutrophils to the endothelium.]] |
Answer C | AnswerC::PECAM 1 |
Answer C Explanation | [[AnswerCExp::PECAM-1 is involved in diapedesis, which is the migration of the neutrophils across the endothelial cells.]] |
Answer D | AnswerD::C5a |
Answer D Explanation | [[AnswerDExp::C5 a is involved in the migration of leykocytes through the interstitum towards the site of inflammation.]] |
Answer E | AnswerE::Interleukin 8 |
Answer E Explanation | [[AnswerEExp::Interleukin 8 is involved in the migration of leukocytes through the interstitium towards the site of inflammation.]] |
Right Answer | RightAnswer::C |
Explanation | [[Explanation::PECAM-1 is involved in diapedesis, which is the migration of the neutrophils across the endothelial cells.
The four steps of extravasation are:
Educational Objective: PECAM 1 is involved in diapedesis, which is the migration of the leukocytes across endothelial cells. |
Approved | Approved::Yes |
Keyword | WBRKeyword::Inflammation, WBRKeyword::Diapedesis, WBRKeyword::Leukocyte, WBRKeyword::Leukocyte adhesion, WBRKeyword::Endothelium, WBRKeyword::Endothelial cell |
Linked Question | Linked:: |
Order in Linked Questions | LinkedOrder:: |