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Other studies have found no association between anticholinergic exposure and risk of developing tardive dyskinesia.<ref name="pmid9546009">{{cite journal |author=van Harten PN, Hoek HW, Matroos GE, Koeter M, Kahn RS |title=Intermittent neuroleptic treatment and risk for tardive dyskinesia: Curaçao Extrapyramidal Syndromes Study III |journal=The American journal of psychiatry |volume=155 |issue=4 |pages=565-7 |year=1998 |pmid=9546009 |doi=}}</ref>
Other studies have found no association between anticholinergic exposure and risk of developing tardive dyskinesia.<ref name="pmid9546009">{{cite journal |author=van Harten PN, Hoek HW, Matroos GE, Koeter M, Kahn RS |title=Intermittent neuroleptic treatment and risk for tardive dyskinesia: Curaçao Extrapyramidal Syndromes Study III |journal=The American journal of psychiatry |volume=155 |issue=4 |pages=565-7 |year=1998 |pmid=9546009 |doi=}}</ref>
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==References==
==References==

Revision as of 22:28, 16 July 2014

Benzatropine
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Clinical data
Pregnancy
category
  • US: C (Risk not ruled out)
Routes of
administration		oral, IM, IV
ATC code
Pharmacokinetic data
Elimination half-life36 hours
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CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
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Chemical and physical data
FormulaC21H25NO
Molar mass307.429 g/mol

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Benzatropine mesilate (INN, commonly known as benztropine; marketed as Cogentin) is an anticholinergic drug principally used for the treatment of:

Indications

It is used in patients with schizophrenia to reduce the side effects of antipsychotic treatment, such as parkinsonism and akathisia.

Benztropine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor but not rigidity or bradykinesia.

Benztropine is also sometimes used for the treatment of dystonia, a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face.

Side effects

These are principally anticholinergic:

Some studies suggest that use of anticholinergics increases the risk of tardive dyskinesia, a long-term side effect of antipsychotics.[1][2]

Other studies have found no association between anticholinergic exposure and risk of developing tardive dyskinesia.[3]

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References

  1. ↑ "Arch Gen Psychiatry -- Abstract: Tardive dyskinesia: prevalence and risk factors, 1959 to 1979, April 1982, Kane and Smith 39 (4): 473". Retrieved 2007-08-14.
  2. ↑ Wszola BA, Newell KM, Sprague RL (2001). "Risk factors for tardive dyskinesia in a large population of youths and adults". Experimental and clinical psychopharmacology. 9 (3): 285–96. PMID 11534539.
  3. ↑ van Harten PN, Hoek HW, Matroos GE, Koeter M, Kahn RS (1998). "Intermittent neuroleptic treatment and risk for tardive dyskinesia: Curaçao Extrapyramidal Syndromes Study III". The American journal of psychiatry. 155 (4): 565–7. PMID 9546009.


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