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| __NOTOC__
| | #REDIRECT [[Aminocaproic acid#Pharmacology]] |
| {{Aminocaproic acid}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Clinical Pharmacology==
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| The fibrinolysis-inhibitory effects of AMICAR appear to be exerted principally via inhibition of [[plasminogen activator]]s and to a lesser degree through antiplasmin activity.
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| In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1). Mean ± SD peak plasma concentrations (164 ± 28 mcg/mL) were reached within 1.2 ± 0.45 hours.
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| After oral administration, the apparent volume of distribution was estimated to be 23.1 ± 6.6 L (mean ± SD). Correspondingly, the volume of distribution after intravenous administration has been reported to be 30.0 ± 8.2 L. After prolonged administration, AMICAR has been found to distribute throughout extravascular and intravascular compartments of the body, penetrating human red blood cells as well as other tissue cells.
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| Renal excretion is the primary route of elimination. Sixty-five percent of the dose is recovered in the urine as unchanged drug and 11% of the dose appears as the metabolite adipic acid. Renal clearance (116 mL/min) approximates endogenous creatinine clearance. The total body clearance is 169 mL/min. The terminal elimination half-life for AMICAR is approximately 2 hours.<ref>{{Cite web | last = | first = | title = DailyMed: Search | url = http://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=Aminocaproic+acid&x=-1148&y=-229 | publisher = | date = | accessdate = 31 January 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Antifibrinolytics]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Amino acids]]
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| [[Category:Antifibrinolytics]]
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| [[Category:Hematology]]
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| [[ja:Ε-アミノカプロン酸]]
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| [[pl:Kwas ε-aminokapronowy]]
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