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| __NOTOC__
| | #REDIRECT [[Bisoprolol#Drug Interactions]] |
| {{Bisoprolol }}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Drug Interactions==
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| ZEBETA should not be combined with other beta-blocking agents. Patients receiving [[catecholamine]]-depleting drugs, such as [[reserpine]] or [[guanethidine]], should be closely monitored, because the added beta-adrenergic blocking action of ZEBETA may produce excessive reduction of sympathetic activity. In patients receiving concurrent therapy with [[clonidine]], if therapy is to be discontinued, it is suggested that ZEBETA be discontinued for several days before the withdrawal of [[clonidine]].
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| ZEBETA should be used with care when myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists (particularly of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes), or antiarrhythmic agents, such as disopyramide, are used concurrently.
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| Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia.
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| Concurrent use of [[rifampin]] increases the metabolic clearance of ZEBETA, resulting in a shortened elimination half-life of ZEBETA. However, initial dose modification is generally not necessary. Pharmacokinetic studies document no clinically relevant interactions with other agents given concomitantly, including [[thiazide]] [[diuretics]], and [[cimetidine]]. There was no effect of ZEBETA on prothrombin time in patients on stable doses of warfarin.
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| ===Risk of Anaphylactic Reaction===
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| While taking beta-blockers, patients with a history of severe [[anaphylactic reaction]] to a variety of allergens may be more reactive to repeated challenge, either accidental, diagnostic, or therapeutic. Such patients may be unresponsive to the usual doses of [[epinephrine]] used to treat allergic reactions.
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| <ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = ZEBETA (BISOPROLOL FUMARATE) TABLET [DURAMED PHARMACEUTICALS, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a11548a0-9c0f-4729-907c-75d8f99a6c85 | publisher = | date = | accessdate = 4 February 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Beta blockers]] | | [[Category:Beta blockers]] |
| [[Category:Cardiovascular Drugs]] | | [[Category:Cardiovascular Drugs]] |
| [[Category:Drugs]] | | [[Category:Drugs]] |
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