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| __NOTOC__
| | #REDIRECT [[Pravastatin#Contraindications]] |
| {{Pravastatin}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Contraindications==
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| ===Hypersensitivity===
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| Hypersensitivity to any component of this medication.
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| ===Liver===
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| Active liver disease or unexplained, persistent elevations of serum transaminases [see Warnings and Precautions (5.2)].
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| ===Pregnancy===
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| [[Atherosclerosis]] is a chronic process and discontinuation of lipid-lowering drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hyper[[Cholesterol]]emia. [[Cholesterol]] and other products of [[Cholesterol]] biosynthesis are essential components for fetal development (including synthesis of steroids and cell membranes). Since statins decrease [[Cholesterol]] synthesis and possibly the synthesis of other biologically active substances derived from [[Cholesterol]], they are contraindicated during pregnancy and in nursing mothers. PRAVASTATIN SHOULD BE ADMINISTERED TO WOMEN OF CHILDBEARING AGE ONLY WHEN SUCH PATIENTS ARE HIGHLY UNLIKELY TO CONCEIVE AND HAVE BEEN INFORMED OF THE POTENTIAL HAZARDS. If the patient becomes pregnant while taking this class of drug, therapy should be discontinued immediately and the patient apprised of the potential hazard to the fetus [see Use in Specific Populations (8.1)].
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| ===Nursing Mothers===
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| A small amount of pravastatin is excreted in human breast milk. Because statins have the potential for serious adverse reactions in nursing infants, women who require PRAVACHOL treatment should not breast-feed their infants [see Use in Specific Populations (8.3)].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = PRAVACHOL (PRAVASTATIN SODIUM) TABLET [E.R. SQUIBB & SONS, L.L.C.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=897ad8b7-921d-eb02-a61c-3419e662a2da | publisher = | date = | accessdate = 18 February 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Statins]]
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| [[Category:Bristol-Myers Squibb]]
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| [[Category:Diols]]
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| [[Category:Carboxylic acids]]
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| [[Category:Carboxylate esters]]
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| [[Category:Naphthalenes]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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