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| {{drugbox
| | #REDIRECT [[Pravastatin]] |
| | IUPAC_name = 3,5-dihydroxy-7- [6-hydroxy-2-methyl-8- (2-methylbutanoyloxy)- 1,2,6,7,8,8a- hexahydronaphthalen-1-yl]- heptanoic acid
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| | image = Pravastatin.png
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| | width = 181
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| | CAS_number = 81093-37-0
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| | ATC_prefix = C10
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| | ATC_suffix = AA03
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| | ATC_supplemental =
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| | PubChem = 54687
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| | DrugBank = APRD00328
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| | C=23 | H=36 | O=7
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| | molecular_weight = 424.528 g/mol
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| | bioavailability =
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| | protein_bound = 50%
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| | metabolism =
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| | elimination_half-life = 77 hours
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| | pregnancy_category =
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| | legal_status =
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| | routes_of_administration =
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| }}
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| {{SI}}
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| {{CMG}}
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| {{Editor Help}}
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| ==[[Pravastatin (patient information)|For patient information, click here]]==
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| ==Overview==
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| In [[medicine]] and [[pharmacology]], '''pravastatin''' ('''Pravachol®''' or Selektine®) is a member of the drug class of [[statin]]s, used for lowering [[cholesterol]] and preventing [[cardiovascular disease]].
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| [[Pravastatin]] was identified originally in a bacterium called ''Nocardia autotrophica'' by researchers of the Sankyo Pharma Inc. It is presently being marketed outside Japan by the [[pharmaceutical company]] Bristol-Myers Squibb.
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| In 2003, Bristol-Myers Squibb announced in a magazine advertisement that [[pravastatin]] is no longer the only statin approved by the FDA proven to reduce the risk of cardiovascular disease, and that [[rosuvastatin]], another statin, is approved to reduce this risk.
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| The [[Food and Drug Administration|U.S. Food and Drug Administration]] approved a generic version of [[Pravastatin]] for sale in the United States for the first time on April 24, 2006. Generic [[Pravastatin|Pravastatin Sodium]] Tablets (10mg, 20mg and 40mg) are manufactured by TEVA Pharmaceuticals in Kfar Sava, Israel. ''[http://www.fda.gov/bbs/topics/NEWS/2006/NEW01363.html FDA Press Release]''
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| In 2005, [[Pravastatin|Pravachol]] was the 22nd highest-selling brand-name drug in the United States. ''[http://www.fda.gov/bbs/topics/NEWS/2006/NEW01363.html FDA Press Release]''
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| == External links ==
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| * [http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a692025.html Pravachol information from the National Institute of Health]
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| * [http://www.bms.com/cgi-bin/anybin.pl?sql=select%20PPI%20from%20TB_PRODUCT_PPI%20where%20PPI_SEQ=56&key=PPI Package insert for Pravachol]
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| {{Statins}}
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| {{SIB}}
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| [[Category:Statins]]
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| [[Category:Bristol-Myers Squibb]]
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| [[Category:Drugs]]
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| [[Category:Cardiology]]
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| [[es:Pravastatina]] [[hu:Pravasztatin]] [[nl:Pravastatine]] [[pl:Prawastatina]] [[th:ปราวาสแตติน]] [[tr:Pravastatin]]
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