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| __NOTOC__
| | #REDIRECT [[Aminocaproic acid#Overdosage]] |
| {{Labetalol}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Overdosage==
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| Overdosage with labetalol HCl causes excessive [[hypotension]] that is posture sensitive and, sometimes, excessive [[[[bradycardia]]]]. Patients should be placed supine and their legs raised if necessary to improve the blood supply to the brain. If overdosage with labetalol HCl follows oral ingestion, gastric lavage or pharmacologically induced [[emesis]] (using syrup of ipecac) may be useful for removal of the drug shortly after ingestion. The following additional measures should be employed if necessary:
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| *Excessive [[[[bradycardia]]]]—administer [[atropine]] or [[epinephrine]].
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| *Cardiac failure—administer a digitalis glycoside and a [[diuretic]].
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| *Dopamine or dobutamine may also be useful.[[hypotension]]—administer [[vasopressors]], e.g., [[norepinephrine]]. There is pharmacologic evidence that [[norepinephrine]] may be the drug of choice.
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| *Bronchospasm—administer [[epinephrine]] and/or an aerosolized beta2-agonist.
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| *Seizures—administer [[diazepam]].
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| In severe beta-blocker overdose resulting in [[hypotension]] and/or [[bradycardia]], [[glucagon]] has been shown to be effective when administered in large doses (5 to 10 mg rapidly over 30 seconds, followed by continuous infusion of 5 mg per hour that can be reduced as the patient improves).
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| Neither [[hemodialysis]] nor [[peritoneal dialysis]] removes a significant amount of labetalol HCl from the general circulation (<1%).
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| The oral LD50 value of labetalol HCl in the mouse is approximately 600 mg/kg and in the rat is >2 g/kg. The IV LD50 in these species is 50 to 60 mg/kg.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = LABETALOL HYDROCHLORIDE TABLET, FILM COATED [WATSON LABORATORIES, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a5b65a9b-6b8a-48a4-9c72-0e605bb309eb | publisher = | date = | accessdate = 5 February 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Beta blockers]] | | [[Category:Beta blockers]] |
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| [[Category:Cardiovascular Drugs]] | | [[Category:Cardiovascular Drugs]] |
| [[Category:Drugs]] | | [[Category:Drugs]] |
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