Amyl nitrite clinical pharmacology: Difference between revisions

Latest revision as of 22:36, 21 July 2014

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+#REDIRECT [[Amyl nitrite#Pharmacology]]
-{{Amyl nitrite}}
-{{CMG}}; {{AE}} {{PB}}
-==Clinical pharmacology==
-Amyl nitrite causes a non specific relaxation of smooth muscle with the most prominent actions occurring in vascular smooth muscle.  This effect on vascular smooth muscle results in coronary [[vasodilation]] and decreased systemic vascular resistance and left ventricular [[preload]] and [[afterload]].  [[Myocardial ischemia]] is relieved in patients with [[angina pectoris]], with an abatement of chest pain and possibly other related symptons. Amyl nitrite vapors are absorbed rapidly through the [[pulmonary alveoli]], manifesting therapeutic effects within one minute after inhalation.  The drug is metabolized rapidly, probably by hydrolytic denitration; approximately one-third of the inhaled amyl nitrite is excreted in the urine.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = AMYL NITRITE INHALANT [JAMES ALEXANDER CORPORATION] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c1b6e536-df5f-4f76-8e3c-6dc2f1e9975e | publisher =  | date =  | accessdate = 30 January 2014 }}</ref>
-==References==
-{{Reflist|2}}
-[[Category:Drugs]]