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| __NOTOC__
| | #REDIRECT [[Isosorbide dinitrate#Clinical Studies]] |
| {{Isosorbide dinitrate}}
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| {{CMG}}; {{AE}} {{PB}}
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| ==Clinical Trials==
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| In clinical trials immediate-release oral ISDN has been administered in a variety of regimens, with total daily doses ranging from 30 mg to 480 mg. Controlled trials of single oral doses of ISDN have demonstrated effective reductions in exercise-related angina for up to 8 hours. [[Anti-anginal]] activity is present about 1 hour after dosing.
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| Most controlled trials of multiple-dose oral ISDN taken every 12 hours (or more frequently) for several weeks have shown statistically significant [[anti-anginal]] efficacy for only 2 hours after dosing. Once-daily regimens, and regimens with one daily dose-free interval of at least 14 hours (e.g., a regimen providing doses at 0800, 1400, and 1800 hours), have shown efficacy after the first dose of each day that was similar to that shown in the single-dose studies cited above. The effects of the second and later doses have been smaller and shorter-lasting than the effect of the first.
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| From large, well-controlled studies of other nitrates, it is reasonable to believe that the maximal achievable daily duration of [[anti-anginal]] effect from ISDN is about 12 hours. No dosing regimen for ISDN, however, has ever actually been shown to achieve this duration of effect. One study of 8 patients, who were administered a pretitrated dose (average 27.5 mg) of immediate-release ISDN at 0800, 1300, and 1800 hours for 2 weeks, revealed that significant [[anti-anginal]] effectiveness was discontinuous and totaled about 6 hours in a 24 hour period.
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| <ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = ISORDIL (ISOSORBIDE DINITRATE) TABLET [BTA PHARMACEUTICALS, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=abb3ad49-73a8-49c5-adc5-164d052971d7 | publisher = | date = | accessdate = 30 January 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Drugs]]
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