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| __NOTOC__
| | #REDIRECT [[Penbutolol#Drug Interactions]] |
| {{Penbutolol}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Drug Interactions==
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| levatol® has been used in combination with hydrochlorothiazide in at least 100 patients without unexpected adverse reactions.
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| In one study, the combination of penbutolol and alcohol increased the number of errors in the eye-hand psychomotor function test.
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| Penbutolol increases the volume of distribution of lidocaine in normal subjects. This could result in a requirement for higher loading doses of lidocaine.
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| Cimetidine has no effect on the clearance of penbutolol. The major metabolite of penbutolol is a glucuronide, and it has been shown that cimetidine does not inhibit glucuronidation.
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| Synergistic hypotensive effects, [[bradycardia]], and arrhythmias have been reported in some patients receiving ß-adrenergic blocking agents when an oral calcium antagonist was added to the treatment regimen.
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| Generally, levatol® should not be used in patients receiving catecholamine-depleting drugs.
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| ===Digoxin===
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| Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of [[bradycardia]].
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| ===Anesthesia===
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| Care should be taken when using anesthetic agents that depress the myocardium, such as ether, [[cyclopropane]], and [[trichloroethylene]], and it is prudent to use the lowest possible dose of levatol®. levatol®, like other ß-blockers, is a competitive inhibitor of ß-receptor agonists, and its effect on the heart can be reversed by cautious administration of such agents (eg, dobutamine or isoproterenol — see OVERDOSAGE). Manifestations of excessive vagal tone (eg, profound [[bradycardia]], [[hypotension]]) may be corrected with [[atropine]] 1 to 3 mg IV in divided doses.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = LEVATOL (PENBUTOLOL SULFATE) TABLET [ACTIENT PHARMACEUTICALS, LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d241fc80-2c55-4dbb-bdb2-44f731afa137 | publisher = | date = | accessdate = 4 February 2014 }}</ref></div>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Beta blockers]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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