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| __NOTOC__
| | #REDIRECT [[Nebivolol#Overdosage]] |
| {{Nebivolol}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Overdosage==
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| In clinical trials and worldwide postmarketing experience there were reports of BYSTOLIC overdose. The most common signs and symptoms associated with BYSTOLIC overdosage are [[bradycardia]]and [[hypotension]]. Other important adverse reactions reported with BYSTOLIC overdose include [[cardiac failure]], [[dizziness]], [[hypoglycemia]], [[fatigue]] and [[vomiting]]. Other adverse reactions associated with [[β-blocker]] overdose include bronchospasm and heart block.
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| The largest known ingestion of BYSTOLIC worldwide involved a patient who ingested up to 500 mg of BYSTOLIC along with several 100 mg tablets of [[acetylsalicylic acid]] in a suicide attempt. The patient experienced [[hyperhydrosis]], pallor, depressed level of consciousness, [[hypokinesia]], [[hypotension]], [[sinus bradycardia]], [[hypoglycemia]], [[hypokalemia]], respiratory failure and vomiting. The patient recovered.
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| Because of extensive drug binding to plasma proteins, [[hemodialysis]] is not expected to enhance nebivolol clearance.
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| If overdose occurs, provide general supportive and specific symptomatic treatment. Based on expected pharmacologic actions and recommendations for other [[β-blocker]]s, consider the following general measures, including stopping BYSTOLIC, when clinically warranted:
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| '''Bradycardia''': Administer IV atropine. If the response is inadequate, isoproterenol or another agent with positive chronotropic properties may be given cautiously. Under some circumstances, transthoracic or transvenous pacemaker placement may be necessary.
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| '''[[hypotension]]''': Administer IV fluids and vasopressors. Intravenous glucagon may be useful.
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| '''Heart Block (second or third degree)''': Monitor and treat with [[isoproterenol]] infusion. Under some circumstances, transthoracic or transvenous pacemaker placement may be necessary.
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| '''Congestive Heart Failure''': Initiate therapy with [[digitalis glycoside]] and [[diuretics]]. In certain cases, consider the use of inotropic and vasodilating agents.
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| '''Bronchospasm''': Administer [[bronchodilator]] therapy such as a short acting inhaled β2-agonist and/or [[aminophylline]].
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| '''[[hypoglycemia]]''': Administer IV [[glucose]]. Repeated doses of IV [[glucose]] or possibly glucagon may be required.
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| Supportive measures should continue until clinical stability is achieved. The half-life of low doses of nebivolol is 12-19 hours.
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| Call the National Poison Control Center (800-222-1222) for the most current information on [[β-blocker]] overdose treatment.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = BYSTOLIC (NEBIVOLOL HYDROCHLORIDE) TABLET [FOREST LABORATORIES, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=8b8ad213-1dc8-454e-a524-075685c0e1a8 | publisher = | date = | accessdate = 4 February 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Beta blockers]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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