|
|
| Line 1: |
Line 1: |
| __NOTOC__
| | #REDIRECT [[Diltiazem#Adverse Reactions]] |
| {{Diltiazem}}
| |
| {{CMG}}; {{AE}} {{AK}}
| |
| | |
| ==Adverse Reactions==
| |
| | |
| Serious adverse reactions have been rare in studies carried out to date, but it should be recognized that patients with impaired ventricular function and cardiac conduction abnormalities usually have been excluded.
| |
| | |
| In domestic placebo-controlled angina trials, the incidence of adverse reactions reported during CARDIZEM therapy was not greater than that reported during placebo therapy.
| |
| | |
| The following represent occurrences observed in clinical studies of [[angina ]]patients. In many cases, the relationship to CARDIZEM has not been established. The most common occurrences from these studies, as well their frequency of presentation, are [[edema ]](2.4%), [[headache ]](2.1%), [[nausea ]](1.9%), [[dizziness ]](1.5%), [[rash ]](1.3%), and [[asthenia ]](1.2%). In addition, the following events were reported infrequently (less than 1 %):
| |
| | |
| '''Cardiovascular:''' [[Angina]], [[arrhythmia]],[[ AV block ]]([[first-degree AV block| first-degree]]), AV block ([[second degree AV block|second-]] or [[third degree AV block|third-degree –]] see [[Diltiazem hydrochloride tablet warnings|WARNINGS, Cardiac Conduction]]), [[bradycardia]], [[bundle branch block]], [[congestive heart failure]], [[ECG]] abnormality, [[flushing]], [[hypotension]], [[palpitations]], [[syncope]], [[tachycardia]], [[ventricular extrasystoles]].
| |
| | |
| '''Nervous System:''' Abnormal dreams, [[amnesia]], [[depression]], [[gait ]]abnormality, [[hallucinations]], [[insomnia]], [[nervousness]], [[paresthesia]], personality change, [[somnolence]], [[tremor]].
| |
| | |
| '''Gastrointestinal:''' [[Anorexia]], [[constipation]], [[diarrhea]], [[dysgeusia]], [[dyspepsia]], mild elevations of [[alkaline phosphatase]], [[SGOT]], [[SGPT]], and [[LDH ]](see [[Diltiazem hydrochloride tablet warnings|WARNINGS, Acute Hepatic Injury]]), [[thirst]], [[vomiting]], weight increase.
| |
| | |
| '''Dermatological:''' [[Petechiae]], [[photosensitivity]], [[pruritus]], [[urticaria]].
| |
| | |
| '''Other:''' [[Amblyopia]], [[CPK ]]elevation, dry mouth, [[dyspnea]], [[epistaxis]], eye irritation, [[hyperglycemia]], [[hyperuricemia]], [[impotence]], [[muscle cramps]], nasal congestion, [[nocturia]], [[osteoarticular pain]], [[polyuria]], [[sexual difficulties]], [[tinnitus]].
| |
| | |
| The following postmarketing events have been reported infrequently in patients receiving CARDIZEM: acute generalized exanthematous [[pustulosis]], allergic reactions, [[alopecia]], [[angioedema ]](including facial or [[periorbital edema]]), [[asystole]], [[erythema multiforme]] (including [[Stevens-Johnson syndrome]], [[toxic epidermal necrolysis]]), [[extrapyramidal symptoms]], [[gingival hyperplasia]], [[hemolytic anemia]], increased [[bleeding time]], [[leukopenia]], [[photosensitivity ]](including lichenoid keratosis and [[hyperpigmentation ]]at sun-exposed skin areas), [[purpura]], [[retinopathy]], [[myopathy]], and [[thrombocytopenia]]. There have been observed cases of a generalized rash, some characterized as [[leukocytoclastic vasculitis]]. In addition, events such as[[ myocardial infarction]] have been observed, which are not readily distinguishable from the natural history of the disease in these patients. A definitive cause and effect relationship between these events and CARDIZEM therapy cannot yet be established. [[Exfoliative dermatitis]] (proven by rechallenge) has also been reported.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = CARDIZEM (DILTIAZEM HYDROCHLORIDE) TABLET, COATED [BTA PHARMACEUTICALS] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=461fe23f-4453-4e3f-9621-0e3fda057d14 | publisher = | date = | accessdate = 5 March 2014 }}</ref>
| |
| | |
| ==References==
| |
| | |
| {{Reflist|2}}
| |
| | |
| [[Category:Cardiovascular Drugs]]
| |
| [[Category:Drugs]]
| |