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| {{drugbox |
| | #REDIRECT [[Felodipine#Pharmacology]] |
| |IUPAC_name = ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro<br>-2,6-dimethyl-3,5- pyridinedicarboxylate
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| | image = Felodipine.png
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| |CAS_number = 72509-76-3
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| | ATC_prefix=C08
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| | ATC_suffix=CA02
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| | PubChem=3333
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| | DrugBank=APRD00374
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| | C=18 | H=19 | Cl=2| N=1 |O =4
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| |molecular_weight = 383.069 g/mol
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| |bioavailability = >95% <ref>{{cite journal| author=Blychert E. | title=Felodipine pharmacokinetics and plasma concentration vs effect relationships | journal=Blood Press Suppl. | volume=2 | issue= | year=1992 | pages=1-30 }}</ref>
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| |metabolism = [[Liver|Hepatic]]
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| |elimination_half-life = ??
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| |excretion = [[Kidney|Renal]]
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| |pregnancy_US = C
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| |legal_status = Rx-only
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| |routes_of_administration = [[Mouth|Oral]]
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| }}
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| __NOTOC__
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| {{CMG}}
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| ==[[Felodipine (patient information)|For patient information, click here]]==
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| ==Overview==
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| '''Felodipine''' is a [[calcium channel blocker]] (calcium antagonist), a drug used to control [[hypertension]] (high blood pressure). It is marketed with the brand name '''Plendil''' by [[AstraZeneca]].
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| ==Interactions==
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| Recent findings have suggested that felodipine in combination with grapefruit juice can cause abnormal (toxic) effects. Oral administration of Felodipine is first metabolized in the gastrointestinal tract (GI) and liver by [[CYP3A4]]. Grapefruit juice is found to have an inhibiting effect over [[cytochrome P450 3A4]]. As a result the [[bioavailability]] of the drug and [[area under the curve]] (AUC) increase, increasing the risk for abnormal side effects. Therefore, special caution must be taken when mixing grapefruit juice with Felodipine.
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| ==References==
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| {{Reflist}}
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| {{Calcium channel blockers}}
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| [[Category:Calcium channel blockers]]
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| [[Category:Drugs]]
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| [[de:Felodipin]]
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| [[fr:Félodipine]]
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| [[hu:Felodipin]]
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