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| __NOTOC__
| | #REDIRECT [[Isradipine#Overdosage]] |
| {{Isradipine}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Overdosage==
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| Minimal empirical data are available on isradipine overdosage. Three individual suicide attempts with dosages of isradipine reported to be from 20 mg up to 100 mg resulted in lethargy, sinus [[tachycardia]]and, in the case of the person ingesting 100 mg, transient [[hypotension ]]which responded to fluid therapy. A foreign report of the ingestion of 200 mg of isradipine with ethanol resulted only in [[flushing]], [[tachycardia]]with ST depression on ECG, and [[hypotension]], all of which were reversible. The ingestion of 5 mg isradipine by a 22-month child and the accidental ingestion of 100 mg of isradipine by a 58-year old female did not result in any sequelae.
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| Available data suggest that, as with other [[dihydropyridines]], overdosage with isradipine might result in excessive peripheral vasodilation with subsequent marked and probably prolonged systemic [[hypotension]], and [[tachycardia]]. Emesis, gastric lavage, administration of activated charcoal followed in 30 minutes by a saline cathartic would be reasonable therapy. Isradipine is highly protein-bound and not removed by [[hemodialysis]]. Overdosage characterized by clinically significant [[hypotension ]]should be treated with active cardiovascular support including monitoring of cardiac and respiratory function, elevation of lower extremities, and attention to circulating fluid volume and urine output. A vasoconstrictor (such as [[epinephrine]], [[norepinephrine]], or [[levarterenol]]) may be helpful in restoring a normotensive state, provided that there is no contraindication to its use.
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| Refractory [[hypotension ]]or AV conduction disturbances may be treated with intravenous calcium salts, or glucagon. Cimetidine should be withheld in such instances due to the risk of further increasing plasma isradipine levels.
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| Significant lethality was observed in mice given oral doses of over 200 mg/kg and rabbits given about 50 mg/kg of isradipine. Rats tolerated doses of over 2000 mg/kg without effects on survival.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = ISRADIPINE CAPSULE [COBALT LABORATORIES] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bf3425e0-428d-4bdb-ac9a-3b9d483df83a | publisher = | date = | accessdate = 28 February 2014 }}</ref>
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| ==References ==
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| {{Reflist|2}}
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| [[Category:Calcium channel blockers]]
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| [[Category:Dihydropyridines]]
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| [[Category:Benzoxadiazoles]]
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| [[Category:Carboxylate esters]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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