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| __NOTOC__
| | #REDIRECT [[Ticagrelor#Nonclinical Toxicology]] |
| {{Ticagrelor}}
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| {{CMG}}; {{AE}} {{JH}}
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| ==Nonclinical Toxicology==
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| ===Carcinogenesis, Mutagenesis, Impairment of Fertility===
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| <u>Carcinogenesis</u>
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| Ticagrelor was not [[carcinogenic]] in the mouse at doses up to 250 mg/kg/day or in the male rat at doses up to 120 mg/kg/day (19 and 15 times the MRHD of 90 mg twice daily on the basis of AUC, respectively). Uterine carcinomas, uterine adenocarcinomas and [[hepatocellular adenoma]]s were seen in female rats at doses of 180 mg/kg/day (29-fold the maximally recommended dose of 90 mg twice daily on the basis of AUC), whereas 60 mg/kg/day (8-fold the MRHD based on AUC) was not carcinogenic in female rats.
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| <u>Mutagenesis</u>
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| Ticagrelor did not demonstrate [[genotoxicity]] when tested in the Ames bacterial mutagenicity test, mouse lymphoma assay and the rat micronucleus test. The active O-demethylated metabolite did not demonstrate [[genotoxicity]] in the Ames assay and mouse lymphoma assay.
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| <u>Impairment of Fertility</u>
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| Ticagrelor had no effect on male [[fertility]] at doses up to 180 mg/kg/day or on female fertility at doses up to 200 mg/kg/day (>15-fold the MRHD on the basis of AUC). Doses of ≥10 mg/kg/day given to female rats caused an increased incidence of irregular duration estrus cycles (1.5-fold the MRHD based on AUC). <ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = BRILINTA (TICAGRELOR) TABLET [ASTRAZENECA LP] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8 | publisher = | date = | accessdate = 26 February 2014 }}</ref>
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| ==References==
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| <ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = BRILINTA (TICAGRELOR) TABLET [ASTRAZENECA LP] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8 | publisher = |date = | accessdate = 26 February 2014 }}</ref>
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| {{Reflist|2}}
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| {{Antithrombotics}}
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| [[Category:ADP receptor inhibitors]]
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| [[Category:Triazolopyrimidines]]
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| [[Category:Organofluorides]]
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| [[Category:Alcohols]]
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| [[Category:AstraZeneca]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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