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| {{CMG}}
| | #REDIRECT [[Heparin#Overdosage]] |
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| ==Overdose==
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| ===Symptoms===
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| Bleeding is the chief sign of Heparin overdosage. [[Nosebleed]]s, [[blood in urine]], or tarry stools may be noted as the first sign of bleeding. Easy [[bruise|bruising]] or [[petechia]]l formations may precede frank bleeding.
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| ===Treatment===
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| '''Neutralization of Heparin effect'''
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| When clinical circumstances (bleeding) require reversal of Heparinization, [[protamine sulfate]] (1% solution) by slow infusion will neutralize Heparin sodium. No more than 50 mg should be administered, very slowly, in any 10-minute period. Each mg of [[protamine sulfate]] neutralizes approximately 100 USP Heparin units. The amount of [[protamine]] required decreases over time as Heparin is metabolized. Although the metabolism of Heparin is complex, it may, for the purpose of choosing a [[protamine]] dose, be assumed to have a half-life of about 1/2 hour after intravenous injection.
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| Administration of [[protamine sulfate]] can cause [[hypotension|severe hypotensive]] and [[anaphylactoid reaction]]s. Because fatal reactions often resembling [[anaphylaxis]] have been reported, the drug should be given only when resuscitation techniques and treatment of [[anaphylactic shock]] are readily available.
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| {{FDA}}
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| [[Category:Drugs]]
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