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| __NOTOC__
| | #REDIRECT [[Prasugrel#Structure]] |
| {{Prasugrel}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Description==
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| Effient contains prasugrel, a [[thienopyridine]] class inhibitor of platelet activation and aggregation mediated by the P2Y12 ADP receptor. Effient is formulated as the hydrochloride salt, a racemate, which is chemically designated as 5-[(1RS)-2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride. Prasugrel hydrochloride has the empirical formula C20H20FNO3S•HCl representing a molecular weight of 409.90. The chemical structure of prasugrel hydrochloride is:
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| Prasugrel hydrochloride is a white to practically white solid. It is soluble at pH 2, slightly soluble at pH 3 to 4, and practically insoluble at pH 6 to 7.5. It also dissolves freely in methanol and is slightly soluble in 1- and 2-propanol and acetone. It is practically insoluble in diethyl ether and ethyl acetate.
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| Effient is available for oral administration as 5-mg or 10-mg elongated hexagonal, film-coated, non-scored tablets, debossed on each side. Each yellow 5-mg tablet is manufactured with 5.49 mg prasugrel hydrochloride, equivalent to 5-mg prasugrel and each beige 10-mg tablet with 10.98 mg prasugrel hydrochloride, equivalent to 10-mg of prasugrel.
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| ===Original Formulation===
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| During manufacture and storage, partial conversion from prasugrel hydrochloride to prasugrel free base may occur. Other ingredients include [[mannitol]], [[hypromellose]], [[croscarmellose sodium]], [[microcrystalline cellulose]], and vegetable magnesium stearate. The color coatings contain [[lactose]], [[hypromellose]], [[titanium dioxide]], [[triacetin]], iron oxide yellow, and iron oxide red (only in Effient 10-mg tablet).
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| ===Revised Formulation===
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| Other ingredients include [[mannitol]], [[hypromellose]], low-substituted hydroxypropyl cellulose, [[microcrystalline cellulose]], sucrose stearate, and glyceryl behenate. The color coatings contain lactose, [[hypromellose]], [[titanium dioxide]], [[triacetin]], iron oxide yellow, and iron oxide red (only in Effient 10-mg tablet).<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5fe9c118-c44b-48d7-a142-9668ae3df0c6 | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5fe9c118-c44b-48d7-a142-9668ae3df0c6 | publisher = | date = | accessdate = 6 February 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Antiplatelet drugs]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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