Disopyramide nonclinical toxicology: Difference between revisions

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Created page with "__NOTOC__ {{Disopyramide}} {{CMG}}; {{AE}} {{SS}} ==Nonclinical Toxicology== Eighteen months of Norpace administration to rats, at oral doses up to 400 mg/kg/day (about 30 t..."
 
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__NOTOC__
#REDIRECT [[Disopyramide#Nonclinical Toxicology]]
{{Disopyramide}}
{{CMG}}; {{AE}} {{SS}}
 
==Nonclinical Toxicology==
 
Eighteen months of Norpace administration to rats, at oral doses up to 400 mg/kg/day (about 30 times the usual daily human dose of 600 mg/day, assuming a patient weight of at least 50 kg), revealed no evidence of carcinogenic potential. An evaluation of mutagenic potential by Ames test was negative. Norpace, at doses up to 250 mg/kg/day, did not adversely affect fertility of rats.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = NORPACE (DISOPYRAMIDE PHOSPHATE) CAPSULE, GELATIN COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e2aa1642-d262-4520-bc6a-9fd3ad795677 | publisher =  | date =  | accessdate = 3 March 2014 }}</ref>
 
 
 
==References==
{{Reflist}}
 
[[Category:Pyridines]]
[[Category:Sodium channel blockers]]
[[Category:Amides]]
[[Category:Cardiovascular Drugs]]
[[Category:Drugs]]

Latest revision as of 02:56, 22 July 2014

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